Melatonin, mitochondria and hypertension

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dc.citation.issue21
dc.citation.volume74
dc.contributor.authorBaltatu, Ovidiu C.
dc.contributor.authorAmaral, Fernanda G. [UNIFESP]
dc.contributor.authorCampos, Luciana A.
dc.contributor.authorCipolla-Neto, Jose
dc.coverageBasel
dc.date.accessioned2020-09-01T13:21:28Z
dc.date.available2020-09-01T13:21:28Z
dc.date.issued2017
dc.description.abstractMelatonin, due to its multiple means and mechanisms of action, plays a fundamental role in the regulation of the organismal physiology by fine tunning several functions. The cardiovascular system is an important site of action as melatonin regulates blood pressure both by central and peripheral interventions, in addition to its relation with the renin-angiotensin system. Besides, the systemic management of several processes, melatonin acts on mitochondria regulation to maintain a healthy cardiovascular system. Hypertension affects target organs in different ways and cellular energy metabolism is frequently involved due to mitochondrial alterations that include a rise in reactive oxygen species production and an ATP synthesis decrease. The discussion that follows shows the role played by melatonin in the regulation of mitochondrial physiology in several levels of the cardiovascular system, including brain, heart, kidney, blood vessels and, particularly, regulating the renin-angiotensin system. This discussion shows the putative importance of using melatonin as a therapeutic tool involving its antioxidant potential and its action on mitochondrial physiology in the cardiovascular system.en
dc.description.affiliationUniv Sao Paulo, Dept Physiol, Inst Biomed Sci, Av Lineu Prestes 1524,Room 115-118, BR-05508000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Physiol, 862 Botucatu St,5th Floor, BR-04023901 Sao Paulo, SP, Brazil
dc.description.affiliationLaureate Int Univ, Anhembi Morumbi Univ, CITE, 500 Dr Altino Bondensan Ave, BR-12247016 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Physiol, 862 Botucatu St,5th Floor, BR-04023901 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)
dc.description.sponsorshipCnpq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
dc.description.sponsorshipIDFAPESP: 2014/50457-0
dc.description.sponsorshipIDCNPq: 446888/2014-1
dc.format.extent3955-3964
dc.identifierhttp://dx.doi.org/10.1007/s00018-017-2613-y
dc.identifier.citationCellular And Molecular Life Sciences. Basel, v. 74, n. 21, p. 3955-3964, 2017.
dc.identifier.doi10.1007/s00018-017-2613-y
dc.identifier.issn1420-682X
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58286
dc.identifier.wosWOS:000412754800007
dc.language.isoeng
dc.publisherSpringer Basel Ag
dc.relation.ispartofCellular And Molecular Life Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMelatoninen
dc.subjectMitochondriaen
dc.subjectCardiovascular systemen
dc.subjectBlood pressureen
dc.subjectHypertensionen
dc.titleMelatonin, mitochondria and hypertensionen
dc.typeinfo:eu-repo/semantics/article
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