Impairments in peripheral blood T effector and T regulatory lymphocytes in bipolar disorder are associated with staging of illness and anti-cytomegalovirus IgG levels

Página do item simplificado
dc.contributor.authorMaes, Michael
dc.contributor.authorNani, João Victor [UNIFESP]
dc.contributor.authorNoto, Cristiano [UNIFESP]
dc.contributor.authorRizzo, Lucas
dc.contributor.authorHayashi, Mirian A. F. [UNIFESP]
dc.contributor.authorBrietzke, Elisa
dc.contributor.authorLatteshttp://lattes.cnpq.br/5559309395232147pt_BR
dc.coverageClifton, NJ
dc.date.accessioned2021-10-29T17:13:07Z
dc.date.available2021-10-29T17:13:07Z
dc.date.issued2020-09-11
dc.description.abstractThere is now evidence that, based on cytokine profiles, bipolar disorder (BD) is accompanied by simultaneous activation of the immune-inflammatory response system (IRS) and the compensatory immune-regulatory system (CIRS), and that both components may be associated with the staging of illness. Nevertheless, no BD studies have evaluated the IRS/CIRS ratio using CD (cluster of differentiation) molecules expressed by peripheral blood activated T effector (Teff) and T regulatory (Treg) subpopulations. This study examined Teff/Treg subsets both before and after ex vivo anti-CD3/CD28 stimulation using flow cytometric immunophenotyping in 25 symptomatic remitted BD patients and 21 healthy controls and assessed human cytomegalovirus (HCMV)-specific IgG antibodies. BD is associated with a significantly lowered frequency of unstimulated CD3 + CD8 + CD71+ and CD4 + CD25 + FOXP3 and increased CD4 + CD25 + FOXP3 + CD152+ frequencies and with lowered stimulated frequencies of CD3 + CD8 + CD71+, CD4 + CD25 + FOXP3 + CD152+, and CD4 + CD25 + FOXP3 + GARP cells and, consequently, by an increased stimulated Teff/Treg ratio. Moreover, the number of manic, but not hypomanic or depressive episodes, is significantly and negatively associated with the stimulated proportions of CD3 + CD4 + CD154+, and CD69+ and CD71+ expression on CD4+ and CD8+ cells, while duration of illness (≥ 10 years) is accompanied by a depleted frequency of stimulated CD152+ Treg, and CD154+ and CD71+ CD4+ T cells. BD and anti-human cytomegalovirus (HCMV) IgG levels significantly interact to decrease the expression of CD4 + CD25 + FOXP+GARP T phenotypes. In conclusion, in BD patients, immune injuries, staging, and HCMV seropositivity interact and cause CIRS dysfunctions and exaggerated IRS responses, which play a key role in parainflammation and neuroaffective toxicity. HCMV seropositivity contributes to an immune-risk phenotype in BD.pt_BR
dc.format.extentp. 229-242
dc.identifierhttps://doi.org/10.1007/s12035-020-02110-1
dc.identifier.citationMolecular Neurobiology, Clifton, NJ, v. 58, n. 1, p. 229-242, Jan. 2021
dc.identifier.doi10.1007/s12035-020-02110-1
dc.identifier.issn1559-1182
dc.identifier.urihttps://hdl.handle.net/11600/62166
dc.languageengpt_BR
dc.publisherHumana Presspt_BR
dc.relation.ispartofMolecular Neurobiologypt_BR
dc.rightsinfo:eu-repo/semantics/openAccesspt_BR
dc.subjectBipolar depressionpt_BR
dc.subjectCytokinespt_BR
dc.subjectInflammationpt_BR
dc.subjectNeuroimmunomodulationpt_BR
dc.subjectPsychoneuroimmunologypt_BR
dc.subjectStagingpt_BR
dc.titleImpairments in peripheral blood T effector and T regulatory lymphocytes in bipolar disorder are associated with staging of illness and anti-cytomegalovirus IgG levelspt_BR
dc.typeinfo:eu-repo/semantics/articlept_BR
unifesp.campusEscola Paulista de Medicina (EPM)pt_BR
unifesp.departamentoFarmacologiapt_BR
unifesp.graduateProgramFarmacologiapt_BR
unifesp.knowledgeAreaOutrapt_BR
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Maes2021_Article_ImpairmentsInPeripheralBloodTE.pdf
Tamanho:
722.94 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Licença do Pacote
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
license.txt
Tamanho:
5.76 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Baixar
Coleções
EPM - Artigos