The contextual fear conditioning deficit presented by spontaneously hypertensive rats (SHR) is not improved by mood stabilizers

Página do item simplificado
dc.contributor.authorCalzavara, Mariana Bendlin [UNIFESP]
dc.contributor.authorMedrano, Wladimir Agostini [UNIFESP]
dc.contributor.authorLevin, Raquel [UNIFESP]
dc.contributor.authorLibanio, Tania Cristina [UNIFESP]
dc.contributor.authorRibeiro, Rosana de Alencar [UNIFESP]
dc.contributor.authorAbilio, Vanessa Costhek [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:05Z
dc.date.available2016-01-24T14:17:05Z
dc.date.issued2011-08-15
dc.description.abstractObjectives: We have recently reported that spontaneously hypertensive rats (SHR) present a contextual fear conditioning (CFC) deficit. This deficit is improved by antipsychotic drugs, potentiated by proschizophrenia manipulations and not altered by acute administration of carbamazepine, lamotrigine and valproic acid. Nevertheless, the effects of lithium a classical mood stabilizer or repeated treatment with these drugs were not evaluated. the main aim of the present study was to extend our previous work by investigating a possible beneficial effect of acute and/or chronic treatments with lithium or lamotrigine on the acquisition deficit of CFC presented by SHR.Methods: Rats were submitted to CFC task after an acute treatment with lithium and/or a repeated treatment with lithium and lamotrigine.Results: Our data revealed that the CFC deficit presented by SHR is not improved by acute or repeated treatment with lithium. Repeated lamotrigine treatment potentiated the deficit presented by SHR and impaired CFC in control animals (Wistar Rats).Conclusions: These data reinforce the absence of beneficial effects of mood stabilizers on the emotional context processing impairment modeled by SHR. (C) 2011 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, LiNC, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pharmacol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, LiNC, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pharmacol, BR-04039032 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1607-1611
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2011.06.005
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 35, n. 7, p. 1607-1611, 2011.
dc.identifier.doi10.1016/j.pnpbp.2011.06.005
dc.identifier.fileWOS000294941800011.pdf
dc.identifier.issn0278-5846
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33957
dc.identifier.wosWOS:000294941800011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectBipolar disorderen
dc.subjectContextual fear conditioningen
dc.subjectLamotrigineen
dc.subjectLithiumen
dc.subjectSchizophreniaen
dc.subjectSHRen
dc.titleThe contextual fear conditioning deficit presented by spontaneously hypertensive rats (SHR) is not improved by mood stabilizersen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000294941800011.pdf
Tamanho:
286.17 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar
Coleções
EPM - Outras produções