Hippocampal plasticity in rats submitted to a gastric restrictive procedure

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dc.contributor.authorFreitas Sonoda, Elisa Yumi de
dc.contributor.authorSilva, Sergio Gomes da [UNIFESP]
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.authorGiglio, Pedro Nogueira
dc.contributor.authorMargarido, Nelson Fontana
dc.contributor.authorReal Martinez, Carlos Augusto
dc.contributor.authorPansani, Aline Priscila
dc.contributor.authorMaciel, Rude de Souza
dc.contributor.authorCavalheiro, Esper Abrao
dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Sao Francisco
dc.contributor.institutionFdn Univ Itaperuna FUNITA
dc.date.accessioned2016-01-24T14:17:12Z
dc.date.available2016-01-24T14:17:12Z
dc.date.issued2011-09-01
dc.description.abstractBariatric surgery has been the most effective therapeutic intervention for morbidly obese patients. However, recent evidence has shown that this procedure may cause serious neurological complications such as Wernicke encephalopathy, depression, and memory impairment. With this in mind, we conducted an experimental study to investigate whether weight-reduction surgery would promote morphological changes in the hippocampal formation, a brain region linked to cognitive and emotional processes. To do so, the present study evaluated the hippocampal expression of parvalbumin interneurons in rats submitted to a gastric restrictive procedure (experimental phytobezoar). Our results demonstrated that rats with gastric-reduced capacity presented a significant increase in the expression of the parvalbumin interneurons in the hippocampal CA1 and CA3 subfields. These data are the first experimental evidence that restrictive bariatric surgery may alter hippocampal cytoarchitecture.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, Disciplina Neurol Expt, Lab Expt Neurol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Surg LIM 02, São Paulo, Brazil
dc.description.affiliationUniv Sao Francisco, Grad Program Hlth Sci, BR-12900000 Braganca Paulista, SP, Brazil
dc.description.affiliationFdn Univ Itaperuna FUNITA, Itaperuna, RJ, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurocirurgia, Disciplina Neurol Expt, Lab Expt Neurol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Physiol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent181-185
dc.identifierhttp://dx.doi.org/10.1179/1476830511Y.0000000009
dc.identifier.citationNutritional Neuroscience. Leeds: Maney Publishing, v. 14, n. 5, p. 181-185, 2011.
dc.identifier.doi10.1179/1476830511Y.0000000009
dc.identifier.issn1028-415X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34036
dc.identifier.wosWOS:000295979300001
dc.language.isoeng
dc.publisherManey Publishing
dc.relation.ispartofNutritional Neuroscience
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBariatric surgeryen
dc.subjectNeuronen
dc.subjectParvalbuminen
dc.subjectHippocampusen
dc.subjectBrainen
dc.subjectPlasticityen
dc.titleHippocampal plasticity in rats submitted to a gastric restrictive procedureen
dc.typeinfo:eu-repo/semantics/article
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