Effect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusion

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dc.citation.issue11
dc.citation.volume32
dc.contributor.authorOkada, Mieko [UNIFESP]
dc.contributor.authorReis Falcao, Luiz Fernando [UNIFESP]
dc.contributor.authorFerez, David [UNIFESP]
dc.contributor.authorMartins, Jose Luiz [UNIFESP]
dc.contributor.authorErrante, Paolo Ruggero [UNIFESP]
dc.contributor.authorMenezes Rodrigues, Francisco Sandro [UNIFESP]
dc.contributor.authorCaricati-Neto, Afonso [UNIFESP]
dc.contributor.authorMarinho, Marcia
dc.contributor.authorFenelon, Guilherme [UNIFESP]
dc.contributor.authorOliveira-Junior, Itamar Souza [UNIFESP]
dc.coverageSao Paulo
dc.date.accessioned2020-09-01T13:21:21Z
dc.date.available2020-09-01T13:21:21Z
dc.date.issued2017
dc.description.abstractPurpose: To investigate the effects of atenolol in inflammatory mediator and oxidative stress in a myocardial injury by intestinal ischemia/reperfusion in rat model. Methods: Adult Wistar male rats were randomly (n= 8), anesthetized and divided in: Sham: submitted to operation only; group SS+ IR: intravenous saline infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); group AT+ IR: intravenous atenolol infusion (2 mg/kg) following superior mesenteric artery occlusion during 60 minutes (ischemia) and open for 120 minutes (reperfusion); and group AT+ I+ AT+ R: intravenous atenolol infusion following superior mesenteric artery occlusion during 60 minutes (ischemia) and in the time 45 minutes other atenolol doses were administrated and the artery was open for 120 minutes (reperfusion), all animals were submitted to muscular relaxation for mechanical ventilation. In the end of experiment the animals were euthanized and the hearts tissue were morphology analyzed by histology and malondialdehyde by ELISA, and the plasma were analyzed for tumor necrosis factor-alpha by ELISA. Results: The group SS+ IR demonstrated the higher malondialdehyde levels when compared with the atenolol treated-groups (p= 0.001) in the heart tissue. The tumor necrosis factoralpha level in plasma decrease in the treated groups when compared with SS+ IR group (p= 0.001). Histology analyses demonstrate pyknosis, edema, cellular vacuolization, presence of inflammatory infiltrate and band contraction in the heart tissue of the rats. Conclusion: Atenolol significantly reduce the degree of cardiac damage after intestinal ischemia-reperfusion.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Postgrad Program Translat Med, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Surg, Div Anesthesia Pain & Intens Med, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Postgrad Program Pharmacol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, Brazil
dc.description.affiliationUNESP, Vet Med Sch, Aracatuba, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Surg, Div Cardiol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Postgrad Program Translat Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Postgrad Program Translat Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Surg, Div Anesthesia Pain & Intens Med, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Postgrad Program Pharmacol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Surg, Div Cardiol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Postgrad Program Translat Med, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFAPESP
dc.format.extent964-972
dc.identifierhttp://dx.doi.org/10.1590/s0102-865020170110000008
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo, v. 32, n. 11, p. 964-972, 2017.
dc.identifier.doi10.1590/s0102-865020170110000008
dc.identifier.fileS0102-86502017001100964.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502017001100964
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58222
dc.identifier.wosWOS:000417846700008
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdrenergic Antagonistsen
dc.subjectAtenololen
dc.subjectIschemiaen
dc.subjectReperfusionen
dc.subjectCytokinesen
dc.subjectOxidative Stressen
dc.subjectRatsen
dc.titleEffect of atenolol pre-treatment in heart damage in a model of intestinal ischemia-reperfusionen
dc.typeinfo:eu-repo/semantics/article
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