Antinociceptive effect of purine nucleotides

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dc.contributor.authorMello, C. F.
dc.contributor.authorBegnini, J.
dc.contributor.authorDeLaVega, D. D.
dc.contributor.authorLopes, F. P.
dc.contributor.authorSchwartz, C. C.
dc.contributor.authorJimenezBernal, R. E.
dc.contributor.authorBellot, Rogerio Gentil [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T16:23:58Z
dc.date.available2018-06-15T16:23:58Z
dc.date.issued1996-10-01
dc.description.abstractThe antinociceptive effect of purine nucleotides administered systemically (sc) was determined using the formalin and writhing tests in adult male albino mice. The mechanisms underlying nucleotide-induced antinociception were investigated by preinjecting the animals (sc) with specific antagonists for opioid (naloxone, 1 mg/kg), purinergic P-1 (caffeine, 5, 10 or 30 mg/kg); theophylline, 10 mg/kg) or purinergic P-2 receptors (suramin, 100 mg/kg, Coomassie blue, 30-300 mg/kg; quinidine, 10 mg/kg). Adenosine, adenosine monophosphate (AMP), diphosphate (ADP) and triphosphate (ATP) caused a reduction in the number of writhes and in the time of licking the formalin-injected paw. Naloxone had no effect on adenosine- or adenine nucleotide-induced antinociception. Caffeine (30 mg/kg) and theophylline (10 mg/kg) reversed the antinociceptive action of adenosine and adenine nucleotide derivatives in both tests. P-2 antagonists did not reverse adenine nucleotide-induced antinociception. These results suggest that the antinociceptive effect of adenine nucleotides is mediated by adenosine.en
dc.description.affiliationUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FARMACOL,BR-04023062 SAO PAULO,BRAZIL
dc.description.affiliationUnifespUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FARMACOL,BR-04023062 SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent1379-1387
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 29, n. 10, p. 1379-1387, 1996.
dc.identifier.issn0100-879X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43096
dc.identifier.wosWOS:A1996VM71000020
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectATPen
dc.subjectpurinergic transmissionen
dc.subjectadenosineen
dc.subjectantinociceptionen
dc.subjectmethylxanthinesen
dc.subjectcaffeineen
dc.subjecttheophyllineen
dc.subjectinflammatory responseen
dc.subjectanti-inflammatory agentsen
dc.subjectP-1 receptorsen
dc.subjectP-2 receptorsen
dc.titleAntinociceptive effect of purine nucleotidesen
dc.typeinfo:eu-repo/semantics/article
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