Single institutional retrospective analysis: treatment of choroidal melanomas with cobalt-60 brachytherapy
dc.contributor.author | Pellizzon, Antônio Cássio Assis | |
dc.contributor.author | Salvajoli, João Victor | |
dc.contributor.author | Novaes, Paulo Eduardo | |
dc.contributor.author | Fogaroli, Ricardo | |
dc.contributor.author | Ferrigno, Robson | |
dc.contributor.author | Maia, Maria Aparecida Conte | |
dc.contributor.author | Chojniak, Marta Motono | |
dc.contributor.author | Erwene, Clélia Maria [UNIFESP] | |
dc.contributor.institution | Hospital do Câncer - AC Camargo Centro de Tratamento Pesquisa Department of Radiation Oncology | |
dc.contributor.institution | Instituto Arnaldo Vieira de Carvalho | |
dc.contributor.institution | Hospital do Câncer - AC Camargo Centro de Tratamento Pesquisa Department of Onco-opthalmology | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.date.accessioned | 2015-06-14T13:31:10Z | |
dc.date.available | 2015-06-14T13:31:10Z | |
dc.date.issued | 2004-06-01 | |
dc.description.abstract | PURPOSE: To evaluate the outcome of patients with choroidal melanoma treated with conservative therapy with brachytherapy (episcleral Co-60 plaque therapy) at the Hospital do Cancer São Paulo, Brazil. METHODS: We evaluated 102 patients consecutively treated from January, 1999 to June, 1999. Median age, maximum tumor base diameter and apex size were 55.5 years, 9.75 mm and 5 mm, respectively. Doses at the base of the tumor, including 1 mm of sclera, ranged from 157 to 487 Gy (median 284.5 Gy) and to the apex from 37 to 220 Gy (median 106 Gy). RESULTS: The crude eye preservation rate with conservative therapy alone was 78.5%. Five-year overall actuarial survival rate was 92.2% and eye conservation rate was 78%. Side effects were mostly an uncomplicated retinopathy in 39/102 patients (38.2%); macular degeneration or scarring led to poor central vision in 31/102 patients (30.3%) of cases. CONCLUSION: Our experience with cobalt-60 plaque brachytherapy achieved a satisfactory rate of local tumor control, despite the oversized base diameters of treated tumors. | en |
dc.description.abstract | OBJETIVOS: Para avaliar o resultado de tratamento pacientes portadores de melanoma de coróide tratados com braquiterapia (placas episclerais de Co-60) no Hospital do Câncer, São Paulo, Brasil. MÉTODOS: Foram avaliados 108 pacientes tratados consecutivamente de janeiro de 1995 a junho de 1999, com idade mediana de 55,5 anos, diâmetro da base do tumor e altura máximos 9,75 mm e 5 mm, respectivamente. As doses na base do tumor, incluindo 1 mm de esclera variaram de 157 a 487 Gy (mediana 284,5 Gy) e para o ápice de 37 até 220 Gy (mediana 106 Gy). RESULTADOS: A taxa de preservação ocular foi 78,5%, com sobrevida atuarial global em cinco anos, e a taxa de conservação ocular atuarial foram 92,2% e 78%, respectivamente. Os principais efeitos colaterais relacionados ao tratamento foram retinopatia em 39/102 (38,2%) pacientes e degeneração macular, levando a déficit visual central em 31/102 (30,3%) pacientes. CONCLUSÃO: Nossa experiência com placas episclerais de Co-60 alcançou taxa satisfatória de controle de tumor local, apesar dos grandes diâmetros das bases dos tumores. | pt |
dc.description.affiliation | Hospital do Câncer - AC Camargo Centro de Tratamento Pesquisa Department of Radiation Oncology | |
dc.description.affiliation | Instituto Arnaldo Vieira de Carvalho | |
dc.description.affiliation | Hospital do Câncer - AC Camargo Centro de Tratamento Pesquisa Department of Onco-opthalmology | |
dc.description.affiliation | Escola Paulista de Medicina Department of Onco-opthalmology | |
dc.description.affiliationUnifesp | UNIFESP, EPM, Department of Onco-opthalmology | |
dc.description.source | SciELO | |
dc.format.extent | 451-454 | |
dc.identifier | http://dx.doi.org/10.1590/S0004-27492004000300015 | |
dc.identifier.citation | Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 67, n. 3, p. 451-454, 2004. | |
dc.identifier.doi | 10.1590/S0004-27492004000300015 | |
dc.identifier.file | S0004-27492004000300015.pdf | |
dc.identifier.issn | 0004-2749 | |
dc.identifier.scielo | S0004-27492004000300015 | |
dc.identifier.uri | http://repositorio.unifesp.br/handle/11600/2136 | |
dc.language.iso | eng | |
dc.publisher | Conselho Brasileiro de Oftalmologia | |
dc.relation.ispartof | Arquivos Brasileiros de Oftalmologia | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Choroid neoplasms | en |
dc.subject | Melanoma | en |
dc.subject | Cobalt radioisotopes | en |
dc.subject | Eye enucleation | en |
dc.subject | Brachytherapy | en |
dc.subject | Radiotherapy dosage | en |
dc.subject | Neoplasias da coróide | pt |
dc.subject | Melanoma | pt |
dc.subject | Radioisótopos de cobalto | pt |
dc.subject | Enucleação ocular | pt |
dc.subject | Braquiteraia | pt |
dc.subject | Dosagem radioterapêutica | pt |
dc.title | Single institutional retrospective analysis: treatment of choroidal melanomas with cobalt-60 brachytherapy | en |
dc.title.alternative | Análise retrospectiva uni-institucional: tratamento de melanomas de coróide com braquiterapia utilizando cobalto-60 | pt |
dc.type | info:eu-repo/semantics/article |
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