Features of host cell invasion by different infective forms of Trypanosoma cruzi

Mortara, Renato Arruda [UNIFESP]; Procópio, Daniela O [UNIFESP]; Barros, Helena C [UNIFESP]; Verbisck, Newton V [UNIFESP]; Andreoli, Walter K [UNIFESP]; Silva, Ricardo Bs [UNIFESP]; Silva, Solange da [UNIFESP]

Features of host cell invasion by different infective forms of Trypanosoma cruzi

Arquivos

S0074-02761999000700014.pdf(42.42 KB)

Data

1999-09-01

Autores

Mortara, Renato Arruda

Procópio, Daniela O

Barros, Helena C

Verbisck, Newton V

Andreoli, Walter K

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Tipo

Artigo

Resumo

Through its life cycle from the insect vector to mammalian hosts Trypanosoma cruzi has developed clever strategies to reach the intracellular milieu where it grows sheltered from the hosts' immune system. We have been interested in several aspects of in vitro interactions of different infective forms of the parasite with cultured mammalian cells. We have observed that not only the classically infective trypomastigotes but also amastigotes, originated from the extracellular differentiation of trypomastigotes, can infect cultured cells. Interestingly, the process of invasion of different parasite infective forms is remarkably distinct and also highly dependent on the host cell type.

Citação

Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 94, p. 135-137, 1999.