Mechanisms of insulin secretion in malnutrition: modulation by amino acids in rodent models

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dc.contributor.authorOliveira, Camila Aparecida Machado de [UNIFESP]
dc.contributor.authorLatorraca, Marcia Queiroz
dc.contributor.authorRostom de Mello, Maria Alice
dc.contributor.authorCarneiro, Everardo Magalhaes
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Fed Mato Grosso UFMT
dc.contributor.institutionUniv Estadual Paulista UNESP
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:21Z
dc.date.available2016-01-24T14:06:21Z
dc.date.issued2011-04-01
dc.description.abstractProtein restriction at early stages of life reduces beta-cell volume, number of insulin-containing granules, insulin content and release by pancreatic islets in response to glucose and other secretagogues, abnormalities similar to those seen in type 2 diabetes. Amino acids are capable to directly modulate insulin secretion and/or contribute to the maintenance of beta-cell function, resulting in an improvement of insulin release. Animal models of protein malnutrition have provided important insights into the adaptive mechanisms involved in insulin secretion in malnutrition. in this review, we discuss studies focusing on the modulation of insulin secretion by amino acids, specially leucine and taurine, in rodent models of protein malnutrition. Leucine supplementation increases insulin secretion by pancreatic islets in malnourished mice. This effect is at least in part due to increase in the expression of proteins involved in the secretion process, and the activation of the PI3K/PKB/mTOR pathway seems also to contribute. Mice supplemented with taurine have increased insulin content and secretion as well as increased expression of genes essential for beta-cell functionality. the knowledge of the mechanisms through which amino acids act on pancreatic beta-cells to stimulate insulin secretion is of interest for clinical medicine. It can reveal new targets for the development of drugs toward the treatment of endocrine diseases, in special type 2 diabetes.en
dc.description.affiliationUniv Estadual Campinas UNICAMP, Dept Anat Biol Celular Fisiol & Biofis, São Paulo, Brazil
dc.description.affiliationUniv Fed Mato Grosso UFMT, Dept Alimentos & Nutr, Fac Nutr, Cuiaba, Mato Grosso, Brazil
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Educ Fis, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo Unifesp, Dept Biociencias, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo Unifesp, Dept Biociencias, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFAPEMAT
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1027-1034
dc.identifierhttp://dx.doi.org/10.1007/s00726-010-0716-y
dc.identifier.citationAmino Acids. New York: Springer, v. 40, n. 4, p. 1027-1034, 2011.
dc.identifier.doi10.1007/s00726-010-0716-y
dc.identifier.issn0939-4451
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33586
dc.identifier.wosWOS:000288546700002
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofAmino Acids
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectMalnutritionen
dc.subjectInsulin secretionen
dc.subjectAmino acidsen
dc.subjectLeucineen
dc.subjectTaurineen
dc.titleMechanisms of insulin secretion in malnutrition: modulation by amino acids in rodent modelsen
dc.typeinfo:eu-repo/semantics/article
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