Characterization and in Vivo Biological Performance of Biosilicate

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dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.contributor.authorBossini, Paulo Sergio [UNIFESP]
dc.contributor.authorCrovace, Murilo Camuri
dc.contributor.authorRodrigues, Ana Candida Martins
dc.contributor.authorZanotto, Edgar Dutra
dc.contributor.authorParizotto, Nivaldo Antonio
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2016-01-24T14:30:52Z
dc.date.available2016-01-24T14:30:52Z
dc.date.issued2013-01-01
dc.description.abstractAfter an introduction showing the growing interest in glasses and glass-ceramics as biomaterials used for bone healing, we describe a new biomaterial named Biosilicate. Biosilicate is the designation of a group of fully crystallized glass-ceramics of the Na2O-CaO-SiO2-P2O5 system. Several in vitro tests have shown that Biosilicate is a very active biomaterial and that the HCA layer is formed in less than 24 hours of exposure to simulated body fluid (SBF) solution. Also, in vitro studies with osteoblastic cells have shown that Biosilicate disks supported significantly larger areas of calcified matrix compared to 45S5 Bioglass, indicating that this bioactive glass-ceramic may promote enhancement of in vitro bone-like tissue formation in osteogenic cell cultures. Finally, due to its special characteristics, Biosilicate has also been successfully tested in several in vivo studies. These studies revealed that the material is biocompatible, presents excellent bioactive properties, and is effective to stimulate the deposition of newly formed bone in animal models. All these data highlight the huge potential of Biosilicate to be used in bone regeneration applications.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Mat Engn, Vitreous Mat Lab, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Fed Sao Carlos, Dept Physiotherapy, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent7
dc.identifierhttps://dx.doi.org/10.1155/2013/141427
dc.identifier.citationBiomed Research International. New York: Hindawi Publishing Corporation, 7 p., 2013.
dc.identifier.doi10.1155/2013/141427
dc.identifier.fileWOS000325377100001.pdf
dc.identifier.issn2314-6133
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/35680
dc.identifier.wosWOS:000325377100001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofBiomed Research International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleCharacterization and in Vivo Biological Performance of Biosilicateen
dc.typeinfo:eu-repo/semantics/article
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