Antioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biome

dc.citation.issue9
dc.citation.volume12
dc.contributor.authorBonamigo, Thaliny
dc.contributor.authorCampos, Jaqueline Ferreira
dc.contributor.authorOliveira, Alex Santos
dc.contributor.authorVieira Torquato, Heron Fernandes [UNIFESP]
dc.contributor.authorPerrella Balestieri, Jose Benedito
dc.contributor.authorLima Cardoso, Claudia Andrea
dc.contributor.authorParedes-Gamero, Edgar Julian
dc.contributor.authorSouza, Kely de Picoli
dc.contributor.authordos Santos, Edson Lucas
dc.coverageSan Francisco
dc.date.accessioned2020-08-04T13:40:12Z
dc.date.available2020-08-04T13:40:12Z
dc.date.issued2017
dc.description.abstractPropolis is a complex bioactive mixture produced by bees, known to have different biological activities, especially in countries where there is a rich biodiversity of plant species. The objective of this study was to determine the chemical composition and evaluate the antioxidant and cytotoxic properties of Brazilian propolis from the species Plebeia droryana and Apis mellifera found in Mato Grosso do Sul, Brazil. In the ethanolic extracts of P. droryana propolis (ExEP-P) and A. mellifera (ExEP-A) acids, phenolic compounds, terpenes and tocopherol were identified as major compounds. Both extracts presented antioxidant activity against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, the maximum activities being 500 mu g/mL (ExEP-P) and 300 mu g/mL (ExEP-A). However, only ExEP-A was able to inhibit lipid peroxidation induced by the oxidizing agent 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH), which inhibited oxidative hemolysis and reduced the levels of malondialdehyde (MDA) in human erythrocytes for 4 h of incubation. The extracts also reduced the cell viability of the K562 erythroleukemia tumour line, with a predominance of necrotic death. Thus, it is concluded that the propolis produced by P. droryana and A. mellifera contain important compounds capable of minimizing the action of oxidizing substances in the organism and reducing the viability of erythroleukemia cells.en
dc.description.affiliationFed Univ Grande Dourados, Res Grp Biotechnol & Bioprospecting Appl Metab GE, Dourados, MS, Brazil
dc.description.affiliationBraz Cubes Univ, Fac Pharm, Francisco Rodrigues Filho Ave, Mogi Das Cruzes, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biochem, R Tres de Maio 100, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estado Mato Grosso, Course Chem, Dourados, MS, Brazil
dc.description.affiliationUniv Mogi das Cruzes, Ctr Interdisciplinary Res Biochem, Av Dr Candido Xavier de Almeida Souza, Mogi Das Cruzes, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biochem, R Tres de Maio 100, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipDevelopment of Education, Science and Technology of Mato Grosso do Sul State - FUNDECT
dc.description.sponsorshipBrazilian National Research Council - CNPq
dc.description.sponsorshipInstituto Nacional de Pesquisa do Pantanal - INPP
dc.description.sponsorshipFundacao de Amparo e Desenvolvimento da Pesquisa - Fadesp
dc.description.sponsorshipFUNDECT
dc.description.sponsorshipCAPES
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0183983
dc.identifier.citationPlos One. San Francisco, v. 12, n. 9, p. -, 2017.
dc.identifier.doi10.1371/journal.pone.0183983
dc.identifier.fileWOS000410449500009.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57361
dc.identifier.wosWOS:000410449500009
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleAntioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biomeen
dc.typeinfo:eu-repo/semantics/article
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