Antioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biome
dc.citation.issue | 9 | |
dc.citation.volume | 12 | |
dc.contributor.author | Bonamigo, Thaliny | |
dc.contributor.author | Campos, Jaqueline Ferreira | |
dc.contributor.author | Oliveira, Alex Santos | |
dc.contributor.author | Vieira Torquato, Heron Fernandes [UNIFESP] | |
dc.contributor.author | Perrella Balestieri, Jose Benedito | |
dc.contributor.author | Lima Cardoso, Claudia Andrea | |
dc.contributor.author | Paredes-Gamero, Edgar Julian | |
dc.contributor.author | Souza, Kely de Picoli | |
dc.contributor.author | dos Santos, Edson Lucas | |
dc.coverage | San Francisco | |
dc.date.accessioned | 2020-08-04T13:40:12Z | |
dc.date.available | 2020-08-04T13:40:12Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Propolis is a complex bioactive mixture produced by bees, known to have different biological activities, especially in countries where there is a rich biodiversity of plant species. The objective of this study was to determine the chemical composition and evaluate the antioxidant and cytotoxic properties of Brazilian propolis from the species Plebeia droryana and Apis mellifera found in Mato Grosso do Sul, Brazil. In the ethanolic extracts of P. droryana propolis (ExEP-P) and A. mellifera (ExEP-A) acids, phenolic compounds, terpenes and tocopherol were identified as major compounds. Both extracts presented antioxidant activity against the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, the maximum activities being 500 mu g/mL (ExEP-P) and 300 mu g/mL (ExEP-A). However, only ExEP-A was able to inhibit lipid peroxidation induced by the oxidizing agent 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH), which inhibited oxidative hemolysis and reduced the levels of malondialdehyde (MDA) in human erythrocytes for 4 h of incubation. The extracts also reduced the cell viability of the K562 erythroleukemia tumour line, with a predominance of necrotic death. Thus, it is concluded that the propolis produced by P. droryana and A. mellifera contain important compounds capable of minimizing the action of oxidizing substances in the organism and reducing the viability of erythroleukemia cells. | en |
dc.description.affiliation | Fed Univ Grande Dourados, Res Grp Biotechnol & Bioprospecting Appl Metab GE, Dourados, MS, Brazil | |
dc.description.affiliation | Braz Cubes Univ, Fac Pharm, Francisco Rodrigues Filho Ave, Mogi Das Cruzes, SP, Brazil | |
dc.description.affiliation | Univ Fed Sao Paulo, Dept Biochem, R Tres de Maio 100, Sao Paulo, SP, Brazil | |
dc.description.affiliation | Univ Estado Mato Grosso, Course Chem, Dourados, MS, Brazil | |
dc.description.affiliation | Univ Mogi das Cruzes, Ctr Interdisciplinary Res Biochem, Av Dr Candido Xavier de Almeida Souza, Mogi Das Cruzes, SP, Brazil | |
dc.description.affiliationUnifesp | Univ Fed Sao Paulo, Dept Biochem, R Tres de Maio 100, Sao Paulo, SP, Brazil | |
dc.description.source | Web of Science | |
dc.description.sponsorship | Development of Education, Science and Technology of Mato Grosso do Sul State - FUNDECT | |
dc.description.sponsorship | Brazilian National Research Council - CNPq | |
dc.description.sponsorship | Instituto Nacional de Pesquisa do Pantanal - INPP | |
dc.description.sponsorship | Fundacao de Amparo e Desenvolvimento da Pesquisa - Fadesp | |
dc.description.sponsorship | FUNDECT | |
dc.description.sponsorship | CAPES | |
dc.format.extent | - | |
dc.identifier | http://dx.doi.org/10.1371/journal.pone.0183983 | |
dc.identifier.citation | Plos One. San Francisco, v. 12, n. 9, p. -, 2017. | |
dc.identifier.doi | 10.1371/journal.pone.0183983 | |
dc.identifier.file | WOS000410449500009.pdf | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://repositorio.unifesp.br/handle/11600/57361 | |
dc.identifier.wos | WOS:000410449500009 | |
dc.language.iso | eng | |
dc.publisher | Public Library Science | |
dc.relation.ispartof | Plos One | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.title | Antioxidant and cytotoxic activity of propolis of Plebeia droryana and Apis mellifera (Hymenoptera, Apidae) from the Brazilian Cerrado biome | en |
dc.type | info:eu-repo/semantics/article |
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