Role of state-dependent learning in the cognitive effects of caffeine in mice

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dc.contributor.authorSanday, Leandro [UNIFESP]
dc.contributor.authorZanin, Karina Agustini [UNIFESP]
dc.contributor.authorPatti, Camilla de Lima [UNIFESP]
dc.contributor.authorFernandes-Santos, Luciano [UNIFESP]
dc.contributor.authorOliveira, Larissa C. [UNIFESP]
dc.contributor.authorLongo, Beatriz Monteiro [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:32:01Z
dc.date.available2016-01-24T14:32:01Z
dc.date.issued2013-08-01
dc.description.abstractCaffeine is the most widely used psychoactive substance in the world and it is generally believed that it promotes beneficial effects on cognitive performance. However, there is also evidence suggesting that caffeine has inhibitory effects on learning and memory. Considering that caffeine may have anxiogenic effects, thus changing the emotional state of the subjects, state-dependent learning may play a role in caffeine-induced cognitive alterations. Mice were administered 20 mg/kg caffeine before training and/or before testing both in the plus-maze discriminative avoidance task (an animal model that concomitantly evaluates learning, memory, anxiety-like behaviour and general activity) and in the inhibitory avoidance task, a classic paradigm for evaluating memory in rodents. Pre-training caffeine administration did not modify learning, but produced an anxiogenic effect and impaired memory retention. While pre-test administration of caffeine did not modify retrieval on its own, the pre-test administration counteracted the memory deficit induced by the pre-training caffeine injection in both the plus-maze discriminative and inhibitory avoidance tasks. Our data demonstrate that caffeine-induced memory deficits are critically related to state-dependent learning, reinforcing the importance of considering the participation of state-dependency on the interpretation of the cognitive effects of caffeine. the possible participation of caffeine-induced anxiety alterations in state-dependent memory deficits is discussed.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurofisiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurofisiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAssociacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorshipIDFAPESP: 1998/14303-3
dc.format.extent1547-1557
dc.identifierhttp://dx.doi.org/10.1017/S1461145712001551
dc.identifier.citationInternational Journal of Neuropsychopharmacology. New York: Cambridge Univ Press, v. 16, n. 7, p. 1547-1557, 2013.
dc.identifier.doi10.1017/S1461145712001551
dc.identifier.issn1461-1457
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36559
dc.identifier.wosWOS:000321547500009
dc.language.isoeng
dc.publisherCambridge Univ Press
dc.relation.ispartofInternational Journal of Neuropsychopharmacology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://journals.cambridge.org/action/displaySpecialPage?pageId=4676
dc.subjectAnxietyen
dc.subjectcaffeineen
dc.subjectmemoryen
dc.subjectretrievalen
dc.subjectstate-dependencyen
dc.titleRole of state-dependent learning in the cognitive effects of caffeine in miceen
dc.typeinfo:eu-repo/semantics/article
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