The brain-heart connection: Implications for understanding sudden unexpected death in epilepsy

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dc.contributor.authorScorza, Fulvio Alexandre [UNIFESP]
dc.contributor.authorArida, Ricardo Mario [UNIFESP]
dc.contributor.authorCysneiros, Roberta Monterazzo [UNIFESP]
dc.contributor.authorTerra, Vera C.
dc.contributor.authorSonoda, Eliza Yumi de Freitas [UNIFESP]
dc.contributor.authorAlbuquerque, Marly de [UNIFESP]
dc.contributor.authorCavalheiro, Esper Abrão [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T16:39:14Z
dc.date.available2018-06-15T16:39:14Z
dc.date.issued2009-09-01
dc.description.abstractEpilepsy is one of the commonest neurological problems worldwide. Approximately 3% of the general population will suffer from epilepsy at some point in their lives. Unfortunately, individuals with epilepsy are at a higher risk of death than the general population, and sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Information concerning risk factors for SUDEP is conflicting, but potential risk factors include young age, early onset of epilepsy, duration of epilepsy, uncontrolled seizures, seizure frequency, antiepileptic drug number and winter temperatures. Although the cause of SUDEP is still unknown, its most commonly suggested mechanisms are cardiac abnormalities during and between seizures. As the anatomical substrate of epileptic activity in the central nervous system shows a direct relation to cardiovascular alterations, this may suggest that patients with epilepsy associated with focal central nervous system lesions may face a particular risk of SUDEP. Currently, experimental and clinical data supports the importance of specific brain structures in the behavioural manifestation, the initiation and the propagation of seizures. Regarding the above findings, our research group focused on this review article that S UDEP could be related to the occurrence of specific brain structure dysfunction or anatomical change, at least in some cases. (Cardiol J 2009; 16, 5: 394-399)en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Disciplina Neurol Expt, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Fisiol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Ctr Ciencias Biol & Saude, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportamento, Ctr Cirurgia Epilepsia CIREP, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Disciplina Neurol Expt, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Fisiol, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent394-399
dc.identifierhttps://journals.viamedica.pl/cardiology_journal/article/view/21453/17057
dc.identifier.citationCardiology Journal. Gdansk: Via Medica, v. 16, n. 5, p. 394-399, 2009.
dc.identifier.fileWOS000271300600002.pdf
dc.identifier.issn1897-5593
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43251
dc.identifier.wosWOS:000271300600002
dc.language.isoeng
dc.publisherVia Medica
dc.relation.ispartofCardiology Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectepilepsyen
dc.subjectsudden cardiac deathen
dc.subjecthearten
dc.subjectcentral nervous systemen
dc.titleThe brain-heart connection: Implications for understanding sudden unexpected death in epilepsyen
dc.typeinfo:eu-repo/semantics/article
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