Neuromyelitis Optica With Onset in Childhood and Adolescence

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dc.contributor.authorFragoso, Yara Dadalti
dc.contributor.authorFerreira, Maria L. B.
dc.contributor.authorOliveira, Enedina M. L. [UNIFESP]
dc.contributor.authorDomingues, Renan B.
dc.contributor.authorRibeiro, Taysa A. G. J.
dc.contributor.authorBrooks, Joseph B. B.
dc.contributor.authorClaudino, Rinaldo
dc.contributor.authorNetto, Jussara M. K.
dc.contributor.authorGomes, Sidney
dc.contributor.authorAdoni, Tarso
dc.contributor.authorCarneiro, Denise S. D.
dc.contributor.authorFonseca, Daiana R. P.
dc.contributor.authorFragomeni, Manuela O. [UNIFESP]
dc.contributor.authorOliveira, Francisco T. M.
dc.contributor.authorOliveira, Celso L. S.
dc.contributor.authorSaldanha, Patricia C. O.
dc.contributor.authorSouza, Jorge M. B.
dc.contributor.institutionUniv Metropolitana Santos
dc.contributor.institutionHosp Restauracao
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSanta Casa Vitoria
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionHosp Beneficencia Portuguesa
dc.contributor.institutionHosp Paulistano
dc.contributor.institutionHosp Sirio Libanes
dc.date.accessioned2016-01-24T14:35:03Z
dc.date.available2016-01-24T14:35:03Z
dc.date.issued2014-01-01
dc.description.abstractBACKGROUND: Neuromyelitis optica with onset before the age of 18 years is a relatively rare, yet potentially devastating condition. the objective of the present study was to contribute to the study of early-onset neuromyelitis optica with a case series. PATIENTS: Data were collected from medical records of Brazilian neurologists caring for patients with neuromyelitis optica occurring in childhood and adolescence. RESULTS: Twenty-nine patients with neuromyelitis optica occurring before the age of 18 years and fulfilling the diagnostic criteria were identified. the average age at disease onset was 13 years and the patients had had an average disease duration of 6 years. the expanded disability scale score at the latest consultation was, on average, 4.7, and one patient had died from the disease. the 29 patients had had an average 4.5 relapses during the disease, accounting for 0.75 relapses per year, irrespective of the medication used. All patients were using one or more of the following medications: azathioprine, prednisone, immunoglobulin, and glatiramer acetate. CONCLUSIONS: Neuromyelitis optica with onset in childhood and adolescence is a poorly understood condition that is often disabling and difficult to manage.en
dc.description.affiliationUniv Metropolitana Santos, Santos, Brazil
dc.description.affiliationHosp Restauracao, Recife, PE, Brazil
dc.description.affiliationUniv Fed Estado São Paulo, São Paulo, Brazil
dc.description.affiliationSanta Casa Vitoria, Fac Ciencias Saude, Vitoria, Brazil
dc.description.affiliationUniv Fed Goias, Goiania, Go, Brazil
dc.description.affiliationUniv Fed Santa Catarina, Florianopolis, SC, Brazil
dc.description.affiliationUniv Fed Rio de Janeiro, Macae, Brazil
dc.description.affiliationHosp Beneficencia Portuguesa, São Paulo, Brazil
dc.description.affiliationHosp Paulistano, São Paulo, Brazil
dc.description.affiliationHosp Sirio Libanes, São Paulo, Brazil
dc.description.affiliationUnifespUniv Fed São Paulo, EPM, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent66-68
dc.identifierhttp://dx.doi.org/10.1016/j.pediatrneurol.2013.07.003
dc.identifier.citationPediatric Neurology. New York: Elsevier B.V., v. 50, n. 1, p. 66-68, 2014.
dc.identifier.doi10.1016/j.pediatrneurol.2013.07.003
dc.identifier.issn0887-8994
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37247
dc.identifier.wosWOS:000329601200011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPediatric Neurology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectneuromyelitis opticaen
dc.subjectDevicen
dc.subjectChildrenen
dc.subjectadolescentsen
dc.subjectdemyelinating diseasesen
dc.subjectmultiple sclerosisen
dc.titleNeuromyelitis Optica With Onset in Childhood and Adolescenceen
dc.typeinfo:eu-repo/semantics/article
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