Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions

dc.contributor.authorFighera, M. R.
dc.contributor.authorQueiroz, C. M.
dc.contributor.authorStracke, M. P.
dc.contributor.authorBrauer, MCN
dc.contributor.authorGonzalez-Rodriguez, L. L.
dc.contributor.authorFrussa, R.
dc.contributor.authorWajner, M.
dc.contributor.authorMello, C. F. de
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande Sul
dc.date.accessioned2016-01-24T12:30:51Z
dc.date.available2016-01-24T12:30:51Z
dc.date.issued1999-07-13
dc.description.abstractTHE effects of chronic administration of alpha-tocopherol or melatonin, or acute ascorbic acid administration on the convulsant action of methylmalonic acid (MMA) were investigated in adult male rats. Animals were chronically injected with alpha-tocopherol (40 mg kg(-1), i.p.), melatonin (5 mg kg(-1), i.p.) or vehicle for 7 days. Buffered MMA (6 mu mol/2 mu l) or NaCl (9 mu mol/2 mu l) was injected intrastriatally and the animals were observed for the appearance of clonic or tonic-clonic convulsions and rotational behavior. Ascorbic acid (100 mg kg(-1), s.c.) was administered 30 min before MMA injection. alpha-Tocopherol and ascorbic acid pretreatment decreased the duration of the convulsive episodes and the rotational behavior elicited by MMA, This study provides evidence that free radical generation may participate in the convulsant effects of methylmalonic acid. NeuroReport 10:2039-2043 (C) 1999 Lippincott Williams & Wilkins.en
dc.description.affiliationUniv Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Satan Maria, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande Sul, Inst Basicas Saude, Dept Bioquim, BR-90050170 Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent2039-2043
dc.identifierhttp://dx.doi.org/10.1097/00001756-199907130-00009
dc.identifier.citationNeuroreport. Philadelphia: Lippincott Williams & Wilkins, v. 10, n. 10, p. 2039-2043, 1999.
dc.identifier.doi10.1097/00001756-199907130-00009
dc.identifier.issn0959-4965
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/26112
dc.identifier.wosWOS:000081354200009
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofNeuroreport
dc.rightsAcesso restrito
dc.subjectantioxidantsen
dc.subjectascorbic aciden
dc.subjectconvulsionen
dc.subjectexcitotoxicityen
dc.subjectglutamateen
dc.subjectmelatoninen
dc.subjectmethylmalonic aciden
dc.subjectsuccinate dehydrogenaseen
dc.subjectalpha-tocopherolen
dc.titleAscorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsionsen
dc.typeArtigo
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