Associação entre Síndrome Metabólica e o padrão de sono em adultos jovens: Estudo Epidemiológico do Sono(EPISONO)
Arquivos
Data
2023-09-25
Autores
Pereira, Nádia Raci Marques 
Orientadores
Hachul, Helena
Tipo
Dissertação de mestrado
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Objetivo: Este estudo investiga a prevalência da Síndrome Metabólica (SM) e a associação entre a SM e o padrão de sono em adultos jovens na cidade de São Paulo. Além disso, foram analisadas as associações de SM com o padrão de sono em mulheres e homens separadamente, e entre os gêneros. Por fim, investigou-se o cronotipo e o gene PER3 estavam associados à SM e ao padrão de sono. Métodos: Esta pesquisa utilizou dados do estudo epidemiológico de sono em São Paulo (EPISONO) 2007, que envolveu 1042 voluntários. Foram incluídos 223 indivíduos na faixa etária de 20 a 39 anos, após a exclusão de pessoas que faziam uso de medicações psicoativas, apresentavam dados incompletos no banco de dados e possuíam apenas um ou dois fatores de risco para a SM. Os participantes responderam a questionários sobre sono e cronotipo, foram submetidos a avaliações antropométricas, aferição da pressão arterial, exames bioquímicos e polissonografia. A amostra foi distribuída em dois grupos: grupo controle (GC) com 180 indivíduos sem fatores de risco para a SM, e grupo síndrome metabólica (GSM) com 43 indivíduos que apresentavam três ou mais dos cinco fatores necessários para o diagnóstico de SM, de acordo com o critério do National Cholesterol Education Program - Adult Treatment Panel III. Foram analisados fatores socioeconômicos, etnia, índice de massa corporal, circunferência da cintura, exames bioquímicos: glicose, HOMA-IR, colesterol total e frações, triglicerídeos, leptina, grelina, proteína C reativa, interleucina 6, fator de necrose tumoral, TGO e TGP. Resultados: A prevalência da SM nessa faixa etária foi menor quando comparada a outros estudos brasileiros. Observou-se associação entre SM e alterações no padrão de sono em adultos jovens, com alto índice de IAH em homens. Não foram encontradas associações da SM com o cronotipo e o gene PER3. Conclusão: Houve associação da SM com a redução da qualidade de sono em adultos jovens independentemente do sexo, mas não com o cronotipo e o gene PER3. Entretanto, faltam estudos que abordem a SM e a qualidade de sono nesta faixa etária. Embora a obesidade possa ter impacto negativo na qualidade do sono, o sono de má qualidade também pode estar associado a fatores de risco para à SM.
Objective: This study investigates the prevalence of Metabolic Syndrome (MetS) and the association between MetS and sleep patterns in young adults in the city of São Paulo. In addition, associations between MS and sleep pattern in women and men were analyzed separately, and between genders. Finally, we investigated the chronotype and the PER3 gene were associated with MS and sleep pattern. Methods: This research used data from the epidemiological study of sleep in São Paulo (EPISONO) 2007, which involved 1042 volunteers. Among these participants, 223 individuals aged between 20 and 39 years were included, after excluding people who used psychoactive medications, had incomplete data in the database and had only one or two risk factors for MS. Participants answered questionnaires about sleep and chronotype, underwent anthropometric assessments, blood pressure measurement, blood tests and polysomnography. The sample was distributed into two groups: control group (CG) with 180 individuals without risk factors for MS, and metabolic syndrome group (GSM) with 43 individuals who presented three or more of the five factors necessary for the diagnosis of MS, according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEPATP III). Socioeconomic factors, ethnicity, body mass index, waist circumference, biochemical tests: glucose, HOMAIR, total cholesterol and fractions, triglycerides, leptin, ghrelin, Creactive protein, interleukin 6, tumor necrosis factor, TGO and TGP were analyzed. Results: The prevalence of MS was lower when compared to other Brazilian studies. An association was observed between MS and changes in sleep patterns in young adults, with a high AHI index in men. No associations were found with chronotype and PER3 gene. Conclusion: There was an association between MS and reduced sleep quality in young adults, regardless of gender, but not with chronotype and PER3 gene. However, there is a lack of studies that address MS and sleep quality in this age group. Although obesity may have a negative impact on sleep quality, poor quality sleep may also be associated with risk factors for MS.
Objective: This study investigates the prevalence of Metabolic Syndrome (MetS) and the association between MetS and sleep patterns in young adults in the city of São Paulo. In addition, associations between MS and sleep pattern in women and men were analyzed separately, and between genders. Finally, we investigated the chronotype and the PER3 gene were associated with MS and sleep pattern. Methods: This research used data from the epidemiological study of sleep in São Paulo (EPISONO) 2007, which involved 1042 volunteers. Among these participants, 223 individuals aged between 20 and 39 years were included, after excluding people who used psychoactive medications, had incomplete data in the database and had only one or two risk factors for MS. Participants answered questionnaires about sleep and chronotype, underwent anthropometric assessments, blood pressure measurement, blood tests and polysomnography. The sample was distributed into two groups: control group (CG) with 180 individuals without risk factors for MS, and metabolic syndrome group (GSM) with 43 individuals who presented three or more of the five factors necessary for the diagnosis of MS, according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEPATP III). Socioeconomic factors, ethnicity, body mass index, waist circumference, biochemical tests: glucose, HOMAIR, total cholesterol and fractions, triglycerides, leptin, ghrelin, Creactive protein, interleukin 6, tumor necrosis factor, TGO and TGP were analyzed. Results: The prevalence of MS was lower when compared to other Brazilian studies. An association was observed between MS and changes in sleep patterns in young adults, with a high AHI index in men. No associations were found with chronotype and PER3 gene. Conclusion: There was an association between MS and reduced sleep quality in young adults, regardless of gender, but not with chronotype and PER3 gene. However, there is a lack of studies that address MS and sleep quality in this age group. Although obesity may have a negative impact on sleep quality, poor quality sleep may also be associated with risk factors for MS.