Effects of subcutaneous carbon dioxide on calcitonin gene related peptide and substance P secretion in rat skin

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dc.contributor.authorRaymundo, Erica Calcagno [UNIFESP]
dc.contributor.authorHochman, Bernardo [UNIFESP]
dc.contributor.authorNishioka, Michele Akemi [UNIFESP]
dc.contributor.authorFreitas, Jose Octavio Gonçalves de [UNIFESP]
dc.contributor.authorMaximino, Jessica Ruivo
dc.contributor.authorChadi, Gerson
dc.contributor.authorFerreira, Lydia Masako [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-06-14T13:47:03Z
dc.date.available2015-06-14T13:47:03Z
dc.date.issued2014-04-01
dc.description.abstractPURPOSE:To investigate the subcutaneous injection of carbon dioxide (CO2) on neuropeptides Calcitonin Gene-Related Peptide (CGRP) and Substance P (SP) secretion in rat skin. METHODS:Fifty-six Wistar-EPM rats were distributed in two groups: one for CGRP analysis, the other for SP analysis. Each group was subdivided into four subgroups: control (Cont), control with needle (ContNd), CO2 injection (CO2Inj) and atmospheric air injection (AirInj) - with seven animals each. Sample analyses of partial skin were conducted by Western Blotting (WB). RESULTS:In SP group, there was a decrease in the amount of neuropeptides in subgroups CO2Inj and AirInj. Similarly, in CGRP group, there was a decrease in the amount of pro-CGRP neuropeptides (15 kDa) in subgroups CO2Inj and AirInj; Nevertheless, there was no decrease in the amount of CGRP (5 kDa) in any subgroups. CONCLUSION:Subcutaneous injection of CO2 and atmospheric air decreased the amount of Substance P and pro-Calcitonin Gene-Related Peptide (15 kDa) neuropeptides in rat skin.en
dc.description.affiliationSão Paulo Federal University
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Department of Surgery
dc.description.affiliationUNIFESP
dc.description.affiliationSão Paulo University School of Medicine Department of Neurology
dc.description.affiliationUSP School of Medicine Department of Neurology
dc.description.affiliationUnifespSão Paulo Federal University
dc.description.affiliationUnifespUNIFESP, Department of Surgery
dc.description.affiliationUnifespUNIFESP
dc.description.sourceSciELO
dc.format.extent224-230
dc.identifierhttps://dx.doi.org/10.1590/S0102-86502014000400002
dc.identifier.citationActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, n. 4, p. 224-230, 2014.
dc.identifier.doi10.1590/S0102-86502014000400002
dc.identifier.fileS0102-86502014000400224.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502014000400224
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/8346
dc.identifier.wosWOS:000334997000002
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarbon Dioxideen
dc.subjectSubstance Pen
dc.subjectCalcitonin Gene-Related Peptideen
dc.subjectNeurogenic Inflammationen
dc.subjectSkinen
dc.subjectRatsen
dc.titleEffects of subcutaneous carbon dioxide on calcitonin gene related peptide and substance P secretion in rat skinen
dc.typeinfo:eu-repo/semantics/article
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