Retinopathy and survival in a population without diabetes the beaver dam eye study

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dc.contributor.authorHirai, Flávio Eduardo [UNIFESP]
dc.contributor.authorMoss, Scot E.
dc.contributor.authorKnudtson, Michael D.
dc.contributor.authorKlein, Barbara E. K.
dc.contributor.authorKlein, Ronald
dc.contributor.institutionUniv Wisconsin
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:49:05Z
dc.date.available2016-01-24T13:49:05Z
dc.date.issued2007-09-15
dc.description.abstractRetinopathy is relatively common in nondiabetic populations, and its long-term prognostic implications are not certain. for this reason, the authors hypothesized that retinal alterations were associated with all-cause and cause-specific mortality in nondiabetic individuals participating in the Beaver Dam Eye Study in Wisconsin. Included in the analysis were 4,294 nondiabetic subjects aged 43-84 years examined at baseline (1988-1990). Retinopathy was classified into four groups by using retinal photographs: 1) no retinopathy, 2) presence of retinal hemorrhages only, 3) presence of retinal microaneurysms only, and 4) presence of moderate or worse retinopathy. the authors analyzed survival during 14 years of follow-up and in 5-year intervals by using time-varying covariates. Baseline prevalence of retinopathy was 7.7%. Adjusting for age, sex, and significant confounders, they observed that moderate retinopathy at baseline was associated with all-cause (hazard ratio = 1.76, 95% confidence interval: 1.16, 2.69) and ischemic heart disease (hazard ratio = 3.17, 95% confidence interval: 1.73, 5.78) mortality after 14 years of follow-up. in the 5-year-interval analysis, the presence of hemorrhages only was significantly related to increased all-cause (hazard ratio = 1.49, 95% confidence interval: 1.05, 2.12) and ischemic heart disease (hazard ratio = 2.43, 95% confidence interval: 1.48, 4.01) mortality. Study results suggest that retinal changes have possible prognostic implications regarding survival of persons without diabetes.en
dc.description.affiliationUniv Wisconsin, Madison Sch Med, Dept Ophthalmol & Visual Sci, Madison, WI 53726 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent724-730
dc.identifierhttp://dx.doi.org/10.1093/aje/kwm126
dc.identifier.citationAmerican Journal of Epidemiology. Cary: Oxford Univ Press Inc, v. 166, n. 6, p. 724-730, 2007.
dc.identifier.doi10.1093/aje/kwm126
dc.identifier.issn0002-9262
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30043
dc.identifier.wosWOS:000249328600013
dc.language.isoeng
dc.publisherOxford Univ Press Inc
dc.relation.ispartofAmerican Journal of Epidemiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.subjecteye diseasesen
dc.subjectmortalityen
dc.subjectophthalmologyen
dc.subjectretinaen
dc.subjectretinal hemorrhageen
dc.titleRetinopathy and survival in a population without diabetes the beaver dam eye studyen
dc.typeinfo:eu-repo/semantics/article
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