Effects of combined zidovudine/lopinavir/ritonavir therapy during rat pregnancy: morphological aspects

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dc.contributor.authorCarvalho, Luisa Patricia Fogarolli de [UNIFESP]
dc.contributor.authorSimoes, Ricardo Santos [UNIFESP]
dc.contributor.authorWagner, A.
dc.contributor.authorTavella, J. S.
dc.contributor.authorOliveira-Filho, Ricardo Martins [UNIFESP]
dc.contributor.authorKulay Júnior, Luiz [UNIFESP]
dc.contributor.authorNakamura, Mary Uchiyama [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Jose do Rosario Velano
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-06-15T16:52:39Z
dc.date.available2018-06-15T16:52:39Z
dc.date.issued2013-01-01
dc.description.abstractPurpose: To evaluate the morphological aspects in rats subjected to an association of the antiretroviral drugs zidovudine/lopinavir/ritonavir in different doses administered throughout the gestational period. Materials and Methods: Forty pregnant rats were randomly allocated into four groups: control (Ctrl) and experimental (Exp1, Exp2, and Exp3), which received zidovudine/lopinavir/ritonavir in the doses of 10/13.3/3.3, 30/39.9/9.9, and 90/119.7/29.7 mg/kg per day from the first to the 20th day of pregnancy, respectively. At term, the animals were euthanized and maternal and fetal organ samples were removed for morphological analysis. Results: No major changes were identified in the group treated with the lowest dosing compared with the control. In group Exp2, the authors found hepatocytes with eosinophilic cytoplasm, pyknotic nuclei, and vasodilation. The proximal convoluted tubules of maternal kidneys showed eosinophilic areas and hyperchromatic nuclei, as well as signs of vasodilation. In the group treated with the highest dose (Exp3); the morphological changes in the maternal kidneys and livers were similar and more pronounced than those found in Exp2. The maternal pancreas of groups Exp2 and Exp3 evidenced moderate and progressive signs of tissue damage. The morphological features of all fetal livers, kidneys, and pancreases were normal. Conclusion: High doses of zidovudine/lopinavir/ritonavir association during the entire rat pregnancy period can cause definite morphological changes in maternal liver, kidneys, and pancreas. On the other hand, the corresponding fetal organs were not affected.en
dc.description.affiliationSao Paulo Fed Univ UNIFESP, Dept Obstet, Sao Paulo, Brazil
dc.description.affiliationUniv Jose do Rosario Velano, Dept Maternal & Child Hlth, Alfenas, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Obstet & Gynecol, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, Brazil
dc.description.affiliationUnifespSao Paulo Fed Univ UNIFESP, Dept Obstet, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent345-349
dc.identifierhttp://www.irog.net/download/?magazine=113
dc.identifier.citationClinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 40, n. 3, p. 345-349, 2013.
dc.identifier.issn0390-6663
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43298
dc.identifier.wosWOS:000343848400009
dc.language.isoeng
dc.publisherI R O G Canada, Inc
dc.relation.ispartofClinical And Experimental Obstetrics & Gynecology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectZidovudineen
dc.subjectLopinaviren
dc.subjectRitonaviren
dc.subjectToxicologyen
dc.subjectPregnancyen
dc.subjectRatsen
dc.titleEffects of combined zidovudine/lopinavir/ritonavir therapy during rat pregnancy: morphological aspectsen
dc.typeinfo:eu-repo/semantics/article
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