Latent Class Analysis of Noninvasive Methods and Liver Biopsy in Chronic Hepatitis C: An Approach without a Gold Standard

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dc.contributor.authorFernandes, Flavia F.
dc.contributor.authorPerazzo, Hugo
dc.contributor.authorAndrade, Luiz E.
dc.contributor.authorDellavance, Alessandra
dc.contributor.authorTerra, Carlos
dc.contributor.authorPereira, Gustavo
dc.contributor.authorPereira, Joao L.
dc.contributor.authorCampos, Frederico
dc.contributor.authorFerraz, Maria L. [UNIFESP]
dc.contributor.authorPerez, Renata M.
dc.coverageLondon
dc.date.accessioned2020-07-17T14:03:31Z
dc.date.available2020-07-17T14:03:31Z
dc.date.issued2017
dc.description.abstractAims. To evaluate the applicability of the Latent Class Analysis (LCA) and accuracy of transient elastography (TE), aspartate-toplatelet- ratio-index (APRI), enhanced liver fibrosis (ELF), and liver biopsy (LB) for liver fibrosis assessment in a model without a gold standard. Methods. Significant fibrosis was defined as TE >= 7.1 kPa, APRI >= 1.5, ELF >= 9.37, or LB METAVIR F >= 2. Cirrhosis was defined as TE >= 12.5 kPa, APRI >= 2.0, ELF >= 10.31, or LB as METAVIR F = 4. Results. 117 patients with chronic hepatitis C were included. In the LCA, for significant fibrosis the sensitivities and specificities (95% CI) were 0.92 (0.86-0.98) and 0.79 (0.72-0.86) for TEen
dc.description.abstract0.47 (0.40-0.54) and 0.99 (0.95-1.00) for APRIen
dc.description.abstract0.81 (0.74-0.88) and 0.78 (0.71-0.85) for ELFen
dc.description.abstractand 0.86 (0.68-1.00) and 0.91 (0.79-1.00) for LB. For cirrhosis, the sensitivities and specificities were 0.92 (0.76-1.00) and 0.94 (0.91-0.97) for TEen
dc.description.abstract0.57 (0.37-0.77) and 0.97 (0.93-1.00) for APRIen
dc.description.abstract0.94 (0.84-1.00) and 0.88 (0.82-0.94) for ELFen
dc.description.abstractand 0.30 (0.12-0.48) and 1.00 for LB. Conclusion. LCA was useful to evaluate accuracy of methods for liver fibrosis staging. Sensitivities and specificities of noninvasive methods were increased in LCA compared to the use of LB as the gold standard.en
dc.description.affiliationUniv Estado Rio De Janeiro, Gastroenterol & Hepatol Dept, Rio De Janeiro, RJ, Brazil
dc.description.affiliationBonsucesso Fed Hosp, Gastroenterol & Hepatol Dept, Rio De Janeiro, RJ, Brazil
dc.description.affiliationFundacao Oswaldo Cruz FIOCRUZ, Natl Inst Infect Dis Evandro Chagas INI, Lab Clin Res HIV AIDS & STD LAPCLIN AIDS, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Rheumatol Dept, Sao Paulo, SP, Brazil
dc.description.affiliationFleury Grp, Dept Res & Dev, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Gastroenterol Dept, Sao Paulo, SP, Brazil
dc.description.affiliationDOr Inst Res & Educ IDOR, Rio De Janeiro, RJ, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Rheumatol Dept, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Gastroenterol Dept, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1155/2017/8252980
dc.identifier.citationBiomed Research International. London, v. , p. -, 2017.
dc.identifier.doi10.1155/2017/8252980
dc.identifier.fileWOS000410605500001.pdf
dc.identifier.issn2314-6133
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55470
dc.identifier.wosWOS:000410605500001
dc.language.isoeng
dc.publisherHindawi Ltd
dc.relation.ispartofBiomed Research International
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleLatent Class Analysis of Noninvasive Methods and Liver Biopsy in Chronic Hepatitis C: An Approach without a Gold Standarden
dc.typeinfo:eu-repo/semantics/article
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