The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry

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dc.citation.issue7]
dc.citation.volume12]
dc.contributor.authorKara-Jose, Andrea C. [UNIFESP]
dc.contributor.authorMelo, Luiz Alberto S., Jr. [UNIFESP]
dc.contributor.authorEsporcatte, Bruno L. B. {UNIFESP]
dc.contributor.authorEndo, Angelica T. N. H. [UNIFESP]
dc.contributor.authorLeite, Mauro Toledo [UNIFESP]
dc.contributor.authorTavares, Ivan Maynart [UNIFESP]
dc.coverageSan Francisco
dc.date.accessioned2020-06-26T16:30:15Z
dc.date.available2020-06-26T16:30:15Z
dc.date.issued2017
dc.description.abstractOur objective was to compare the diagnostic accuracies of and to determine the correlations between the disc damage likelihood scale (DDLS) and anatomical and functional tests used for glaucoma detection. A total of 54 healthy subjects (54 eyes) and 47 primary open-angle glaucoma patients (47 eyes) were included in this cross-sectional observational study. DDLS scores and cup-to-disc (C/D) ratios were evaluated. Subjects underwent standard automated perimetry (SAP), optic disc and retinal nerve fiber layer (RNFL) imaging with time and spectral-domain optical coherence tomography (TD and SD-OCT), Heidelberg Retina Tomograph (HRT II), and scanning laser polarimetry (GDx-VCC). Areas under the receiver operating characteristic curves (AROCs) for DDLS and diagnostic tests parameters were calculated. DDLS correlations (Spearman's rank) among these parameters were analyzed. Fifty-four eyes were healthy and 47 had glaucoma, including 16 preperimetric glaucoma. DDLS, vertical and horizontal C/D ratios had the largest AROCs (0.92, 0.94 and 0.91, respectively). DDLS diagnostic accuracy was better than the accuracies of HRT II parameters, TD and SD-OCT RNFL thicknesses, and SAP mean deviation (MD) index. There were no significant differences between the accuracies of the DDLS and the C/D ratios, TD-OCT vertical (0.89) and horizontal (0.86) C/D ratios, TD-OCT C/D area ratio (0.89), and GDx-VCC NFI (0.81). DDLS showed significant strong correlations with vertical (r = 0.79) and horizontal (0.74) C/D ratios, and with the parameters vertical C/D ratio and C/D area ratio from HRT II (both 0.77) and TD-OCT (0.75 and 0.72, respectively). DDLS had significant moderate correlations with most of the other structural measurements and SAP MD. The optic disc clinical evaluation with DDLS system and C/D ratio demonstrated excellent accuracy in distinguishing glaucomatous from healthy eyes. DDLS had moderate to strong correlations with most structural and functional parameters. These findings stress the importance of optic disc clinical examination to detect glaucoma in a clinical scenario.en
dc.description.affiliationUniv Fed Sao Paulo, Escola Paulista Med, Dept Ophthalmol & Visual Sci, Glaucoma Div, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Escola Paulista Med, Dept Ophthalmol & Visual Sci, Glaucoma Div, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCAPES/Ministry of Education of Brazil
dc.description.sponsorshipCNPq/Ministry of Science and Technology of Brazil
dc.description.sponsorshipIDCAPES
dc.description.sponsorshipIDCNPq
dc.format.extent-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0181428]
dc.identifier.citationPlos One. San Francisco, v. 12, n. 7, p. -, 2017.
dc.identifier.doi10.1371/journal.pone.0181428
dc.identifier.fileWOS000406634500071.pdf
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/53441
dc.identifier.wosWOS:000406634500071
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleThe disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetryen
dc.typeinfo:eu-repo/semantics/article
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