Adhesio interthalamica alterations in schizophrenia spectrum disorders: A systematic review and meta-analysis

dc.contributor.authorTrzesniak, Clarissa
dc.contributor.authorKempton, Matthew J.
dc.contributor.authorBusatto, Geraldo F.
dc.contributor.authorOliveira, Irismar Reis de
dc.contributor.authorGalvao-de Almeida, Amanda [UNIFESP]
dc.contributor.authorKambeitz, Joseph
dc.contributor.authorFreitas Ferrari, Maria Cecilia
dc.contributor.authorSantos Filho, Alaor
dc.contributor.authorChagas, Marcos H. N.
dc.contributor.authorZuardi, Antonio W.
dc.contributor.authorHallak, Jaime E. C.
dc.contributor.authorMcGuire, Phillip K.
dc.contributor.authorCrippa, Jose Alexandre S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionKings Coll London
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.abstractMagnetic resonance imaging (MRI) studies have reported a variety of brain abnormalities in association with schizophrenia. These include a higher prevalence of an absent adhesio interthalamica (Al; also known massa intermedia), a gray matter junction that is present between the two thalami in approximately 80% of healthy subjects. in this meta-analytic review, we describe and discuss the main Al MRI findings in schizophrenia spectrum disorders (SSDs) to date. the MEDLINE and ISI Web of Knowledge(SM) databases were searched up to December 2010, for studies that used MRI to assess Al in patients with SSD and controls. From fourteen potential reports, eleven were eligible to be part of the current review. These studies included 822 patients with SSD and 718 healthy volunteers. There was a large degree of variability in the MRI methods they employed. Patients with SSD had a higher prevalence of absent Al than healthy volunteers (odds ratio = 1.98; 95% confidence interval 1.33-2.94: p=0.0008). This association was evident in both male and female SSD subjects, and there was no evidence that the prevalence was related to age or duration of illness. the significance of the absence of an Al for SSD may be clarified by studies in large, longitudinal community-based samples using standardized methods. (C) 2011 Elsevier Inc. All rights reserved.en
dc.description.affiliationUSP, FMRP, Sch Med, Dept Neurosci & Behav Sci, BR-14048900 Ribeirao Preto, SP, Brazil
dc.description.affiliationKings Coll London, Inst Psychiat, Dept Psychosis, London, England
dc.description.affiliationUniv São Paulo, Sch Med, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUniv Fed Bahia, Affect Disorders Ctr, Salvador, BA, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Post Grad Program, São Paulo, Brazil
dc.description.affiliationLiNC, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Post Grad Program, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), São Paulo (SP), Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDCAPES: 5797/09-8
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 35, n. 4, p. 877-886, 2011.
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsAcesso restrito
dc.subjectAdhesio interthalamicaen
dc.subjectMagnetic resonance imagingen
dc.subjectMassa intermediaen
dc.titleAdhesio interthalamica alterations in schizophrenia spectrum disorders: A systematic review and meta-analysisen