Homeopathic Plumbum metallicum for lead poisoning: a randomized clinical trial

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dc.contributor.authorPadilha, Roberto Queiroz
dc.contributor.authorRiera, Rachel [UNIFESP]
dc.contributor.authorAtallah, Alvaro Nagib [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionHosp Sirio Libanes
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:16:58Z
dc.date.available2016-01-24T14:16:58Z
dc.date.issued2011-07-01
dc.description.abstractIntroduction: Poisoning due to lead and its compounds has short and long-term effects primarily on the nervous, hematopoietic, gastrointestinal, cardiovascular, musculoskeletal, renal and reproductive systems. It can manifest in acute or chronic symptoms. Measuring serum concentration is the primary method for diagnosing and monitoring exposed workers. Presently, elevated lead levels are treated by drugs whose effectiveness is contested on various fronts. Experimental studies suggest that homeopathic preparations may be in controlling blood lead levels in laboratory animals, creating the need for controlled studies to evaluate the effectiveness and safety of these preparations in humans.Objective: To evaluate the effectiveness of the homeopathic preparation Plumbum metallicum in reducing the blood lead level of workers exposed to this metal.Design: Double-blind randomized trial.Setting: Workers' clinic in the Ajax battery plant, which employs 900 workers with varying degrees of lead exposure in Bauru, São Paulo State, Brazil.Subjects: 131 workers exposed to lead.Intervention: Plumbum metallicum 15cH or placebo, orally for 35 days.Results: the percentage of workers who demonstrated a reduction in lead counts by a percentage greater than or equal to 25% following treatment was the same for both groups: 20.3% in the homeopathic groups versus 21% in the control group [Relative Risk (RR) = 0.95, confidential interval (Cl) 95%: 0.47-1.92)]. Analysis by intention-to-treat also did not show any difference between the groups: 18.2% in the treated group versus 20% in the placebo group (RR = 0.91, Cl 95%: 0.45-1.84).Conclusion: the homeopathic preparation Plumbum metallicum had no effect, in this study, in terms of reducing serum lead in workers exposed to lead. Homeopathy (2011) 100, 116-121.en
dc.description.affiliationUniv Fed Sao Carlos, Dept Med, São Paulo, Brazil
dc.description.affiliationHosp Sirio Libanes, Teaching & Res Inst, Sirio Libanes, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Brazilian Cochrane Ctr, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent116-121
dc.identifierhttp://dx.doi.org/10.1016/j.homp.2010.11.007
dc.identifier.citationHomeopathy. Oxford: Elsevier B.V., v. 100, n. 3, p. 116-121, 2011.
dc.identifier.doi10.1016/j.homp.2010.11.007
dc.identifier.issn1475-4916
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33857
dc.identifier.wosWOS:000293610100003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofHomeopathy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectLead poisoningen
dc.subjectControlled clinical trialen
dc.subjectEffectivenessen
dc.subjectPlumbum Metallicumen
dc.subjectHomeopathic drugen
dc.titleHomeopathic Plumbum metallicum for lead poisoning: a randomized clinical trialen
dc.typeinfo:eu-repo/semantics/article
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