Methadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholamines

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dc.citation.volume37
dc.contributor.authorPignaton, Wangles
dc.contributor.authorLuna, Stelio Pacca Loureiro
dc.contributor.authorTeixeira Neto, Francisco Jose
dc.contributor.authorde Oliveira, Flavia Augusta
dc.contributor.authorde Castro Neto, Eduardo Ferreira [UNIFESP]
dc.contributor.authorNaffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.authorGozalo-Marcilla, Miguel
dc.coverageNew York
dc.date.accessioned2020-10-30T18:46:27Z
dc.date.available2020-10-30T18:46:27Z
dc.date.issued2016
dc.description.abstractCatecholamines and arginine vasopressin (AVP) release can affect arterial blood pressure (ABP) and hemodynamic stability in standing, sedated horses. Six mature horses were included in this prospective, randomized, crossover, blinded, experimental study. All the horses were sedated with detomidine (DET) alone (0.01 mg/kg, IV) or combined with methadone (MET) (0.01 mg/kg DET and 0.2 mg/kg MET, IV). Cardiopulmonary data and blood samples were collected 30 minutes before (prebaseline and baseline) and for 120 minutes postinjection. The combination DET/MET produced a significant increase (31%) in mean ABP (MAP) 5 minutes after drug administration which lasted for 120 minutes. Detomidine alone induced only a short-term increase in MAP (15%) at 5 minutes compared with baseline. There were significant differences between groups at 5, 15, and from 60 to 120 minutes. Plasma AVP concentrations were higher in horses receiving the treatment DET from 60 to 120 minutes than those in the combination group, for the same period. There were no significant differences in norepinephrine and epinephrine serum concentrations respect to baseline and between treatments. Detomidine induces a short-term MAP increase, and this effect was prolonged and potentiated by MET association. There is no evidence of AVP, norepinephrine, and epinephrine involvement in this effect. (C) 2016 Elsevier Inc. All rights reserved.en
dc.description.affiliationUNESP Univ Estadual Paulista, Sch Med, Dept Anesthesiol, Sao Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, Dist Rubiao Jr S-N, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Biochem, Escola Paulista Med, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biochem, Escola Paulista Med, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.description.sponsorshipIDFAPESP: 2008/56362-0
dc.format.extent39-45
dc.identifierhttps://doi.org/10.1016/j.jevs.2015.10.014
dc.identifier.citationJournal Of Equine Veterinary Science. New York, v. 37, p. 39-45, 2016.
dc.identifier.doi10.1016/j.jevs.2015.10.014
dc.identifier.issn0737-0806
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/58468
dc.identifier.wosWOS:000370377900006
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofJournal Of Equine Veterinary Science
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCardiovascular systemen
dc.subjectAdrenergic alpha-2 agonisten
dc.subjectAnalgesicen
dc.subjectOpioiden
dc.subjectEquineen
dc.subjectArterial blood pressureen
dc.titleMethadone Increases and Prolongs Detomidine-Induced Arterial Hypertension in Horses, but These Effects Are Not Mediated by Increased Plasma Concentrations of Arginine Vasopressin or Serum Concentrations of Catecholaminesen
dc.typeinfo:eu-repo/semantics/article
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