The composition and behavior of capsules around smooth and textured breast implants in pigs

dc.contributor.authorMinami, Eliza
dc.contributor.authorKoh, Ivan Hong Jun [UNIFESP]
dc.contributor.authorRonche Ferreira, Jose Carlos
dc.contributor.authorLogullo Waitzberg, Angela Flavia
dc.contributor.authorChifferi, Valcir
dc.contributor.authorRosewick, Tomas Fortoul
dc.contributor.authorPereira, Max Domingues
dc.contributor.authorNascimento Saldiva, Paulo Hilario
dc.contributor.authorPoli de Figueiredo, Luiz Francisco [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:29Z
dc.date.available2016-01-24T12:41:29Z
dc.date.issued2006-09-15
dc.description.abstractBackground: the surface of the implant is one of the many factors often associated with the occurrence of capsular contracture, the etiopathogeny of which remains unclear. the purpose of this study was to analyze the behavior of capsular contracture by means of applanation tonometry and histology using a midsized animal model.Methods: Silicone breast implants were implanted into 33 pigs and observed at 30, 60, 180, and 270 postoperative days.Results: Capsular contracture in smooth implants showed significantly greater pressure values of tonometry, and the smooth implant capsule was significantly thicker than the textured implant capsule. Both pressure and thickness of the capsules increased at each period. the collagenous layer did not show any difference considering the periods of time in which the total thickness was analyzed; on the other hand, the increase in total capsular thickness occurred by thickening of the noncollagenous layer in both smooth and textured implants. Taking into consideration both kinds of implants, histomorphometric analysis showed that thin fibers were replaced by thick fibers in later postoperatives periods (180 and 270 days).Conclusions: the greater incidence of capsular contracture in smooth implants was correlated with the progressive increase in total capsule thickness, due to a higher concentration of collagenous fibers, when compared with textured implants (p = 0.011; mean difference, 6.61), and a higher concentration of thick fibers (p = 0.034; average, > 5.51 percentage points per field of thick fibers than the textured implants in all periods). Pigs are good animal models for studying the healing process after breast augmentation with implants.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, BR-04532060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, BR-04532060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, BR-04532060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, BR-04532060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent874-884
dc.identifierhttp://dx.doi.org/10.1097/01.prs.0000240878.24213.b7
dc.identifier.citationPlastic and Reconstructive Surgery. Philadelphia: Lippincott Williams & Wilkins, v. 118, n. 4, p. 874-884, 2006.
dc.identifier.doi10.1097/01.prs.0000240878.24213.b7
dc.identifier.issn0032-1052
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29157
dc.identifier.wosWOS:000240700100006
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofPlastic and Reconstructive Surgery
dc.rightsAcesso restrito
dc.titleThe composition and behavior of capsules around smooth and textured breast implants in pigsen
dc.typeArtigo
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