Transcranial Doppler ultrasonography in adults with sickle cell disease

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dc.contributor.authorValadi, N.
dc.contributor.authorSilva, G. S.
dc.contributor.authorBowman, L. S.
dc.contributor.authorRamsingh, D.
dc.contributor.authorVicari, P.
dc.contributor.authorFilho, A. C.
dc.contributor.authorMassaro, A. R.
dc.contributor.authorKutlar, A.
dc.contributor.authorNichols, F. T.
dc.contributor.authorAdams, R. J.
dc.contributor.institutionMed Coll Georgia
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:24Z
dc.date.available2016-01-24T12:41:24Z
dc.date.issued2006-08-22
dc.description.abstractBackground: Transcranial Doppler (TCD) is used to select children with sickle cell disease (SCD) for primary stroke prevention using regular blood transfusion. Whether it can also identify high stroke risk in adults with SCD is not known. Methods: the authors examined 112 adult patients from two convenience population samples with SCD and 53 healthy control subjects to compare velocities in adults to those reported in children with SCD and to evaluate the influence of age and hematocrit on TCD. Results: Adults with SCD had a higher mean time-averaged maximum mean velocity (110.9 +/- 25.7 cm/s) compared with healthy controls (71.1 +/- 12.0 cm/s), and the difference is approximately proportional to their anemia. No cases with velocities >= 200 cm/s (the threshold used in children for prophylactic treatment) were found in this sample. Conclusions: Transcranial Doppler velocities in adults with sickle cell disease ( SCD) are lower than those in children with SCD. Velocity criteria used in children cannot be used to stratify risk of stroke in adults.en
dc.description.affiliationMed Coll Georgia, Dept Neurol, Augusta, GA 30912 USA
dc.description.affiliationMed Coll Georgia, Dept Hematol, Augusta, GA 30912 USA
dc.description.affiliationMed Coll Georgia, Sch Nursing, Augusta, GA 30912 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Hematol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Infect Dis, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Hematol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Infect Dis, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent572-574
dc.identifierhttp://dx.doi.org/10.1212/01.wnl.0000230150.39429.8e
dc.identifier.citationNeurology. Philadelphia: Lippincott Williams & Wilkins, v. 67, n. 4, p. 572-574, 2006.
dc.identifier.doi10.1212/01.wnl.0000230150.39429.8e
dc.identifier.issn0028-3878
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29093
dc.identifier.wosWOS:000239920100008
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofNeurology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleTranscranial Doppler ultrasonography in adults with sickle cell diseaseen
dc.typeinfo:eu-repo/semantics/article
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