Physico-chemical characterization and biocompatibility of hydroxyapatite derived from fish waste

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dc.citation.volumev. 80
dc.contributor.authorYamamura, Hirochi [UNIFESP]
dc.contributor.authorSilva, Victor Hugo Pereira da [UNIFESP]
dc.contributor.authorRuiz, Pedro Luiz Menin
dc.contributor.authorUssui, Valter [UNIFESP]
dc.contributor.authorLazar, Dolores Ribeiro Ricci
dc.contributor.authorRenno, Ana Claudia Muniz [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.coverageAmsterdam
dc.date.accessioned2020-07-20T16:31:11Z
dc.date.available2020-07-20T16:31:11Z
dc.date.issued2018
dc.description.abstractThe aim of this study was to synthesize hydroxyapatite (HAP) powder from fish waste. The powder was characterized through X-ray diffraction, Fourier transform infrared spectroscopy, ion exchange chromatography, scanning electron microscopy and plasma emission spectrometry. The cyto- and genotoxicity was carried out to demonstrate biocompatibility in vivo by means of rat subcutaneous tissue test. The results showed that the visible crystalline nature of typical apatite crystal structure when they were calcined at 800 degrees C. Infrared spectroscopy analysis showed similar composition to HAP standard with the presence of carbonate ion demonstrated by wave number values of 871 cm(-1) and 1420 cm(-1) for calcinations at 800 degrees C. The scanning electronmicrographies depicted the crystal morphology and porous nature with average pore size of similar to 10 mu m. Plasma emission spectrometry and ion exchange chromatography confirmed the presence of Ca and P in the samples. The mean of calcium content was 36.8en
dc.description.abstractMg was 0.8, Na was 0.7 and K was 0.5. Rat subcutaneous tissue test revealed that HAP presented biocompatibility. Furthermore, the lack of cyto- and genotoxicity in blood, liver, kidney and lung were noticed after 30 days of HAP implantation. Taken together, our results demonstrated that HAP from fish waste exhibits a great potential for using as biomaterial since is represents a simple, effective, low-cost process and satisfactory degree of biocompatibility.en
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Biosci, Av Ana Costa 95, BR-11060001 Santos, SP, Brazil
dc.description.affiliationIPEN, Nucl & Energy Res Inst, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespFed Univ Sao Paulo UNIFESP, Dept Biosci, Av Ana Costa 95, BR-11060001 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
dc.description.sponsorshipIDCNPq: 442149/2014-0
dc.format.extent137-142
dc.identifierhttp://dx.doi.org/10.1016/j.jmbbm.2018.01.035
dc.identifier.citationJournal Of The Mechanical Behavior Of Biomedical Materials. Amsterdam, v. 80, p. 137-142, 2018.
dc.identifier.doi10.1016/j.jmbbm.2018.01.035
dc.identifier.issn1751-6161
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55764
dc.identifier.wosWOS:000428486800018
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal Of The Mechanical Behavior Of Biomedical Materials
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHydroxyapatiteen
dc.subjectBiomaterialsen
dc.subjectBiocompatibilityen
dc.subjectRaten
dc.subjectWhitemouth croakeren
dc.subjectFish wasteen
dc.titlePhysico-chemical characterization and biocompatibility of hydroxyapatite derived from fish wasteen
dc.typeinfo:eu-repo/semantics/article
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