Genetic polymorphisms of vitamin D receptor (VDR), CYP27B1 and CYP24A1 genes and the risk of colorectal cancer

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dc.citation.issue2
dc.citation.volume32
dc.contributor.authorVidigal, Veronica Marques [UNIFESP]
dc.contributor.authorSilva, Tiago Donizetti [UNIFESP]
dc.contributor.authorde Oliveira, Juliana [UNIFESP]
dc.contributor.authorMarques Pimenta, Celia Aparecida [UNIFESP]
dc.contributor.authorFelipe, Aledson Vitor [UNIFESP]
dc.contributor.authorForones, Nora Manoukian [UNIFESP]
dc.coverageMilan
dc.date.accessioned2020-07-17T14:02:25Z
dc.date.available2020-07-17T14:02:25Z
dc.date.issued2017
dc.description.abstractIntroduction: Vitamin D receptor (VDR) and proteins encoded by the genes CYP27B2 and CYP24A1 involved in the production and inactivation of vitamin D can influence vitamin D and the susceptibility to colorectal cancer (CRC). The objective of this study was to investigate the relationship between the risk of CRC and polymorphisms in VDR, CYP27B1 and CYP24A1, lifestyle and dietary habits. Methods: The study included 152 patients with CRC and 321 controls. All participants answered a questionnaire on their dietary habits, alcohol consumption and smoking habits. DNA was extracted from peripheral blood. Polymorphisms of BsmI and ApaI were identified by performing PCR-RFLP. Identification of CYP24A1 (rs6013897, rs158552 and rs17217119) and CYP27B1 (rs10877012) polymorphisms was performed by gene sequencing. Results: Smoking, alcohol use, and low or no consumption of fruit, cereals and dairy products were associated with an increased risk of CRC. A heterozygous genotype Aa or an association genotype aa + Aa of the VDR ApaI polymorphism increased the risk of CRC. The VDR BsmI polymorphism was not significantly associated with the risk of CRC. Multivariate analysis showed that heterozygous and association genotype AT + AA of the rs6013897 polymorphism, genotype CT of the rs158552 polymorphism, association genotype CT + CC and genotypes AA and GG of the rs17217119 polymorphism of CYP24A1, and heterozygous genotype GT and association genotype GT + TT of the rs10877012 polymorphism in CYP27B1 were associated with a higher risk of CRC. Conclusions: Dietary habits, lifestyle, and polymorphisms in VDR (ApaI), CYP24A1 (rs6013897, rs158552, rs17217119) and CYP27B1 (rs10877012) were associated with a higher risk of CRC.en
dc.description.affiliationUniv Fed Sao Paulo, Gastroenterol Dept, Oncol Div, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Gastroenterol Dept, Oncol Div, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP)
dc.format.extentE224-E230
dc.identifierhttp://dx.doi.org/10.5301/jbm.5000248
dc.identifier.citationInternational Journal Of Biological Markers. Milan, v. 32, n. 2, p. E224-E230, 2017.
dc.identifier.doi10.5301/jbm.5000248
dc.identifier.issn0393-6155
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54794
dc.identifier.wosWOS:000400857800008
dc.language.isoeng
dc.publisherWichtig Publishing
dc.relation.ispartofInternational Journal Of Biological Markers
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectColorectal canceren
dc.subjectCYP24A1en
dc.subjectCYP27B1en
dc.subjectPolymorphismen
dc.subjectVitamin Den
dc.subjectVDRen
dc.titleGenetic polymorphisms of vitamin D receptor (VDR), CYP27B1 and CYP24A1 genes and the risk of colorectal canceren
dc.typeinfo:eu-repo/semantics/article
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