CARDIOVASCULAR EFFECTS PRODUCED BY MICROINJECTION of ANGIOTENSIN-(1-7) ON VASOPRESSOR and VASODEPRESSOR SITES of the VENTROLATERAL MEDULLA

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dc.contributor.authorSilva, LCS
dc.contributor.authorFontes, MAP
dc.contributor.authorCampagnolesantos, M. J.
dc.contributor.authorKhosla, M. C.
dc.contributor.authorCampos, R. R.
dc.contributor.authorGuertzenstein, P. G.
dc.contributor.authorSantos, RAS
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCLEVELAND CLIN EDUC FDN
dc.date.accessioned2016-01-24T11:40:13Z
dc.date.available2016-01-24T11:40:13Z
dc.date.issued1993-06-11
dc.description.abstractIn this study, we determined the cardiovascular effects produced by micro-injection of the heptapeptide Angiotensin-(1-7) [Ang-(1-7)] into the rat ventrolateral medulla (VLM). Micro-injection of Ang-(1-7) into the rostral VLM and the caudal pressor area of the VLM produced significant increases in arterial pressure, comparable to that observed with micro-injection of Ang II. the changes in arterial pressure were associated with more variable changes in heart rate (HR) (usually tachycardia). On the other hand, micro-injection of Ang-(1-7) into the caudal depressor area induced decreases in arterial pressure and HR. the results suggest that, besides Ang II, Ang-(1-7) is involved in the mediation of the cardiovascular actions of the renin-angiotensin system in the VLM.en
dc.description.affiliationUNIV FED MINAS GERAIS,INST CIENCIAS BIOL,DEPT FISIOL & BIOFIS,HIPERTENSAO LAB,BR-31270 BELO HORIZON,MG,BRAZIL
dc.description.affiliationESCOLA PAULISTA MED,DEPT FISIOL,BR-04023 São Paulo,BRAZIL
dc.description.affiliationCLEVELAND CLIN EDUC FDN,CLEVELAND,OH 44106
dc.description.affiliationUnifespESCOLA PAULISTA MED,DEPT FISIOL,BR-04023 São Paulo,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent321-325
dc.identifierhttp://dx.doi.org/10.1016/0006-8993(93)90920-I
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 613, n. 2, p. 321-325, 1993.
dc.identifier.doi10.1016/0006-8993(93)90920-I
dc.identifier.issn0006-8993
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25334
dc.identifier.wosWOS:A1993LH29300023
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectVENTROLATERAL MEDULLAen
dc.subjectANGIOTENSIN-IIen
dc.subjectANGIOTENSIN-(1-7)en
dc.subjectVASOMOTOR ACTIVITYen
dc.titleCARDIOVASCULAR EFFECTS PRODUCED BY MICROINJECTION of ANGIOTENSIN-(1-7) ON VASOPRESSOR and VASODEPRESSOR SITES of the VENTROLATERAL MEDULLAen
dc.typeinfo:eu-repo/semantics/article
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