Current Knowledge of Trichosporon spp. and Trichosporonosis

dc.contributor.authorColombo, Arnaldo L. [UNIFESP]
dc.contributor.authorPadovan, Ana Carolina B. [UNIFESP]
dc.contributor.authorChaves, Guilherme M.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande do Norte
dc.description.abstractTrichosporon spp. are basidiomycetous yeast-like fungi found widely in nature. Clinical isolates are generally related to superficial infections. However, this fungus has been recognized as an opportunistic agent of invasive infections, mostly in cancer patients and those exposed to invasive medical procedures. It is possible that the ability of Trichosporon strains to form biofilms on implanted devices, the presence of glucuronoxylomannan in their cell walls, and the ability to produce proteases and lipases are all factors likely related to the virulence of this genus and therefore may account for the progress of invasive trichosporonosis. Disseminated trichosporonosis has been increasingly reported worldwide and represents a challenge for both diagnosis and species identification. Phenotypic identification methods are useful for Trichosporon sp. screening, but only molecular methods, such as IGS region sequencing, allow the complete identification of Trichosporon isolates at the species level. Methods for the diagnosis of invasive trichosporonosis include PCR-based methods, Luminex xMAP technology, and, more recently, proteomics. Treating patients with trichosporonosis remains a challenge because of limited data on the in vitro and in vivo activities of antifungal drugs against clinically relevant species of the genus. Despite the mentioned limitations, the use of antifungal regimens containing triazoles appears to be the best therapeutic approach.en
dc.description.affiliationUniversidade Federal de São Paulo, Lab Especial Micol, Disciplina Infectol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Lab Micol Med Mol, Dept Anal Clin Toxicol, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Lab Especial Micol, Disciplina Infectol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2005/02006-0
dc.description.sponsorshipIDFAPESP: 2005/04442-1
dc.description.sponsorshipIDFAPESP: 2007/08575-1
dc.description.sponsorshipIDCNPq: 308011/2010-4
dc.description.sponsorshipIDCAPES: PNPD 02640-09-0
dc.identifier.citationClinical Microbiology Reviews. Washington: Amer Soc Microbiology, v. 24, n. 4, p. 682-+, 2011.
dc.publisherAmer Soc Microbiology
dc.relation.ispartofClinical Microbiology Reviews
dc.rightsAcesso aberto
dc.titleCurrent Knowledge of Trichosporon spp. and Trichosporonosisen
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
501.38 KB
Adobe Portable Document Format