Experimental paracoccidioidomycosis in high and low antibody responder mice of Selection IV-A

dc.contributor.authorSoares, Angela Maria Victoriano de Campos
dc.contributor.authorRezkallah-Iwasso, Maria Thereza
dc.contributor.authorOliveira, S. L.
dc.contributor.authorPeraçoli, Maria Terezinha Serrão
dc.contributor.authorMontenegro, Mário Rubens Guimarães
dc.contributor.authorMusatti, Chloe Camba [UNIFESP]
dc.contributor.institutionUNESP
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:03:58Z
dc.date.available2018-06-18T11:03:58Z
dc.date.issued2000-08-01
dc.description.abstractHigh (H) and low (L) responder mice were selected for their ability to produce antibodies against sheep and human erythrocytes (Selection IV-A). In this selection, the difference in antibody responsiveness between H and L lines (HIV-A and LIV-A mice, respectively) was shown to depend mainly on macrophage function. The more rapid catabolism of antigens by macrophages in L mice has been suggested as the main cause of the low antibody production. Due to this high macrophage activity, L animals have been described as more resistant than H animals to intracellular pathogens. These animals were utilized as an experimental model of paracoccidioidomycosis. HIV-A and LIV-A mice were infected with Paracoccidioides brasiliensis by the intravenous route. As expected, H mice were more susceptible to P. brasiliensis with a shorter survival time and higher levels of specific antibodies when compared to L mice. Contrasting with the survival time, the lungs, spleen and liver from H mice showed typical nodular granulomas containing epithelioid and giant cells and few fungi. On the other hand, in LN-A mice, the lesions of these organs were characterized by looser granulomas with irregular borders and the presence of a large number of fungi, However, the adrenal gland showed different lesion patterns. In H mice these lesions were extensive and characterized by loose granulomas with numerous fungi, while in LIV-A mice the lesions were small and limited to the cortex. Moreover the HIV-A mice presented higher levels of serum corticosterone when compared to LIV-A ones. The higher susceptibility of H mice could be attributed to the extensive lesions of the adrenal glands. These results suggest the use of the H line from the IV-A Selection as an experimental model for further studies of adrenal involvement in paracoccidioidomycosis.en
dc.description.affiliationUNESP, Biosci Inst, Dept Microbiol & Immunol, BR-18618000 Sao Paulo, Brazil
dc.description.affiliationUNESP, Sch Med, Dept Pathol, Botucatu, SP, Brazil
dc.description.affiliationUNIFESP, Dept Pediat, Sao Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Pediat, Sao Paulo, Brazil
dc.description.provenanceMade available in DSpace on 2018-06-18T11:03:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2000-08-01en
dc.description.sourceWeb of Science
dc.format.extent309-315
dc.identifierhttp://www.tandfonline.com/doi/abs/10.1080/mmy.38.4.309.315
dc.identifier.citationMedical Mycology. Oxford: B I O S Scientific Publishers Ltd, v. 38, n. 4, p. 309-315, 2000.
dc.identifier.issn1369-3786
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/44872
dc.identifier.wosWOS:000089248300004
dc.language.isoeng
dc.publisherB I O S Scientific Publishers Ltd
dc.relation.ispartofMedical Mycology
dc.rightsAcesso restrito
dc.subjectadrenal glanden
dc.subjecthistopathologyen
dc.subjectmurine experimental paracoccidioidomycosisen
dc.titleExperimental paracoccidioidomycosis in high and low antibody responder mice of Selection IV-Aen
dc.typeArtigo
Arquivos
Coleções