Antimicrobial resistance of isolated Streptococcus pneumoniae in a hospital of the Brazilian public system

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Pinheiro, Claudia Maria França
Pereira, Edimar Cristiano [UNIFESP]
Ferreira, Karen Spadari [UNIFESP]
Batista, Wagner [UNIFESP]
Junqueira, Virginia Berlanga Campos [UNIFESP]
Azzalis, Ligia Ajaime [UNIFESP]
Chaves, Loide Corina
Rocha, Katya Cristina
Abreu, Luiz Carlos de
Fonseca, Alexandre Luiz Affonso [UNIFESP]
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Streptococcus pneumoniae is the predominant bacterial agent that affects the human population with pneumonia. This disease is an important cause of death in the elderly and the children under five years old. in this study, 29 strains of invasive S. pneumoniae were isolated from 29 patients of pneumonia, bacteremia and meningitis in the laboratory of the Municipal Hospital in Paulinia, Brazil, from May 2006 to October 2007. Patients' age ranged from 8 months old to 60 years old. These strains of S. pneumoniae were isolated from blood, pleural fluid and cerebrospinal fluid (CSF) of patients. After typing of encapsulated strains of S. pneumoniae through quellung reaction, their resistance to antimicrobial agents was gauged through Disc Diffusion Technique followed by determination of minimum inhibitory concentration (MIC). Among the 29 strains analyzed, 23 were methicillin-sensitive and six were methicillin-resistant and penicillin intermediate resistant. No strain presented full resistance to penicillin. Serotyping was performed only in two samples, which belonged to serotype 18. Our data may alert ambulatory regarding the incidence of pneumococcal strains resistant to the most common drugs due to inappropriate use of antimicrobials and also collaborate to the elaboration of pneumococcal conjugate vaccines specific to each region.
African Journal of Microbiology Research. Victoria Island: Academic Journals, v. 6, n. 6, p. 1113-1117, 2012.