The role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapy

dc.citation.volume33
dc.contributor.authorMasquio, Deborah Cristina Landi [UNIFESP]
dc.contributor.authorPiano Ganen, Aline de
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorCampos, Raquel Munhoz da Silveira [UNIFESP]
dc.contributor.authorSantamarina, Aline Boveto [UNIFESP]
dc.contributor.authorSouza, Gabriel Inacio de Morais Honorato de [UNIFESP]
dc.contributor.authorGomes, Aline Dal'Olio
dc.contributor.authorMoreira, Renata Guimaraes
dc.contributor.authorCorgosinho, Flavia Campos [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorTock, Lian
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.coverageNew York
dc.date.accessioned2020-08-14T13:44:30Z
dc.date.available2020-08-14T13:44:30Z
dc.date.issued2016
dc.description.abstractThe purpose of the present study was to evaluate if interdisciplinary therapy can influence the cardiometabolic and serum free fatty acid profile. The second aim was to evaluate if there is an association between serum free fatty acids, inflammation and cardiometabolic biomarkers in obese adolescents with and without metabolic syndrome submitted to a long-term interdisciplinary therapy. The study involved 108 postpuberty obese adolescents, who were divided according to metabolic syndrome (MetS) diagnosis: MetS (n=32) and Non-MetS (n=76). The interdisciplinary therapy consisted of a 1-year period of nutrition, psychology, physical exercise and clinical support. After therapy, both groups improved metabolic, inflammatory (leptin, adiponectin, leptin/adiponectin ratio, adiponectin/leptin ratio and C-reactive protein) and cardiometabolic profile (PAI-1 and ICAM). Metabolic syndrome prevalence reduced from 28.70% to 12.96%. Both groups reduced myristic acid (C14:0) and increased docosahexaenoic acid (DHA, C22:6n3), heneicosapentaenoic acid (HPA, C21:5n3) and arachidonic acid (C20:4n6). After adjustment for metabolic syndrome and the number of metabolic syndrome parameters, multiple regression analysis showed that changes in VCAM and PAI-1 were negatively associated with changes in cis-linoleic acid (C18:2n6c). Additionally, changes in trans-linoleic acid (C18:2n6t) were also positively associated with these biomarkers. Moreover, leptin and leptin/adiponectin ratio were negatively associated with changes in docosapentaenoic acid (DPA, C22:5n3) and stearidonic acid (SDA, C18:4n3). Adiponectin/leptin ratio was positively associated with docosapentaenoic acid (DPA, C22:5n3). Changes in adiponectin were positively correlated with changes in omega 3, such as heneicosapentaenoic acid (HPA, C21:5n3) and docosapentaenoic acid (DPA, C22:5n3). Results support that interdisciplinary therapy can control inflammatory and cardiometabolic profile in obese adolescents. Moreover, serum fatty acids can be influenced by lifestyle changes and are able to modulate these biomarkers. (C) 2016 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Programa Posgrad Nutr, Sao Paulo, Brazil
dc.description.affiliationCtr Univ Sao Camilo, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Lab Fisiol Nutr, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biociencias, Dept Fisiol Geral, BR-05508 Sao Paulo, Brazil
dc.description.affiliationWeight Sci, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Psicobiol, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Programa Posgrad Nutr, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Psicobiol, UNIFESP, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidade Federal de São Paulo (UNIFESP)
dc.description.sponsorshipAFIP
dc.description.sponsorshipCEPE
dc.description.sponsorshipCEMSA
dc.description.sponsorshipIDCNPq: 141533/2012-9
dc.description.sponsorshipIDCNPq: 300654/2013-8
dc.description.sponsorshipIDCAPES: AUX-PE-PNPD 2566/2011
dc.description.sponsorshipIDFAPESP: 2011/50356-0
dc.description.sponsorshipIDFAPESP: 2011/50414-0
dc.description.sponsorshipIDFAPESP: 2013/041364
dc.format.extent136-144
dc.identifierhttps://dx.doi.org/10.1016/j.jnutbio.2016.03.017
dc.identifier.citationJournal Of Nutritional Biochemistry. New York, v. 33, p. 136-144, 2016.
dc.identifier.doi10.1016/j.jnutbio.2016.03.017
dc.identifier.issn0955-2863
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57702
dc.identifier.wosWOS:000378011400016
dc.language.isoeng
dc.publisherElsevier Science Inc
dc.relation.ispartofJournal Of Nutritional Biochemistry
dc.rightsAcesso restrito
dc.subjectFree fatty acidsen
dc.subjectInflammationen
dc.subjectCardiometabolicen
dc.subjectInterdisciplinaryen
dc.subjectMetabolic syndromeen
dc.subjectAdolescentsen
dc.titleThe role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapyen
dc.typeArtigo
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