Angiotensin Converting Enzyme 90 kDa isoform: Biomarker for diagnosis of preeclampsia?

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dc.contributor.authorKrauspenhar, Bruna
dc.contributor.authorSontag, Fernando
dc.contributor.authorRonchi, Fernanda A. [UNIFESP]
dc.contributor.authorCasarini, Dulce E. [UNIFESP]
dc.contributor.authorPoli-de-Figueiredo, Carlos Eduardo
dc.contributor.authorPinheiro da Costa, Bartira E.
dc.contributor.institutionPontificia Univ Catolica Rio Grande do Sul
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:38:07Z
dc.date.available2016-01-24T14:38:07Z
dc.date.issued2014-11-01
dc.description.abstractPreeclampsia (PE), one of the leading gestational hypertensive diseases, is characterized by increased blood pressure (>= 140/90 mm Hg) and pathological proteinuria after 20 weeks gestation. It is a complex, multifactorial syndrome with an unestablished etiology and cure. the search continues for a biomarker that could assist in the early prediction or diagnosis of PE, reducing the rate of maternal and fetal mortality. Based on the findings of Casarini et al. that suggest the 90 kDa isoform of the Angiotensin Converting Enzyme (ACE) as a possible marker of hypertension, we hypothesized that this isoform may be present in pregnant women with PE, since they present a transient and spontaneous model of systemic arterial hypertension in pregnancy.We believe, therefore, that pregnant women with pure PE (PPE) express the ACE 90 kDa isoform in urine, as well as having elevated isoform enzymatic activity, during pregnancy only. Postpartum, with the normalization of blood pressure, the protein isoform would no longer be expressed. Pregnant women with superimposed preeclampsia (SPE) would present the ACE 90 kDa isoform both during and after the gestation period, and its enzymatic activity would remain high as they are chronically hypertensive. It is expected that normotensive pregnant women do not present this isoform in their urine as elevated blood pressure levels do not occur. Both normotensive and PPE affected pregnant women with a family history of hypertension, will possibly express the ACE 90 kDa isoform before pregnancy and may become hypertensive, only after some years, through the influence of environmental factors and/or other diseases.If our hypothesis is confirmed, it will allow differentiation of PPE and SPE sooner than 12 weeks postpartum, which is currently the estimated period for confirmation of the specific diagnosis. Furthermore, it could be an early biomarker for predicting the disease, enabling the physician to choose the best clinical management. in addition, it would minimize the use of other methods as the biological sample for obtaining the marker is urine, a practical and effective test with good reproducibility. Finally, test results would enable a greater understanding of the mechanisms involved in gestational hypertension. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationPontificia Univ Catolica Rio Grande do Sul, Sao Lucas Hosp, Grad Program Med & Hlth Sci Nephrol, Sch Med,Inst Biomed Res, Porto Alegre, RS, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Med, Div Nephrol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Rio Grande do Sul (FAPERGS)
dc.format.extent526-529
dc.identifierhttp://dx.doi.org/10.1016/j.mehy.2014.09.009
dc.identifier.citationMedical Hypotheses. Edinburgh: Churchill Livingstone, v. 83, n. 5, p. 526-529, 2014.
dc.identifier.doi10.1016/j.mehy.2014.09.009
dc.identifier.issn0306-9877
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38402
dc.identifier.wosWOS:000345181700002
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofMedical Hypotheses
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.titleAngiotensin Converting Enzyme 90 kDa isoform: Biomarker for diagnosis of preeclampsia?en
dc.typeinfo:eu-repo/semantics/article
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