Sleep patterns over 15-day period in rats with spinal cord injury

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dc.contributor.authorEsteves, A. M.
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorSquarcini, C. F. R.
dc.contributor.authorLancellotti, Carmen Lucia Penteado
dc.contributor.authorComparoni, Aniella [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSanta Casa
dc.date.accessioned2016-01-24T13:48:37Z
dc.date.available2016-01-24T13:48:37Z
dc.date.issued2007-05-01
dc.description.abstractStudy design: Experimental, controlled trial.Objectives: the purpose of this study was to evaluate over a 15-day period alterations in sleep pattern of rats after spinal cord injury (SCI).Setting: Federal University of São Paulo, Department of Psychobiology.Methods: in total, 20 male Wistar rats were used. the rats were divided in two groups: SHAM and SCI. the rats were submitted to the following procedures: electrode insertion surgery, 24 h duration baseline sleep recording, SCI (level T9) and subsequent sleep recording for 15 consecutive days.Results: the results showed a reduction in sleep efficiency in the light period for Days 1-3, 5, 10 and 12 after SCI in relation to the SHAM group, with alterations in total waking time and sleep stages. Limb movements were observed 4 days after SCI.Conclusion: the present findings suggest that SCI may be heavily involved in altering sleep pattern in SCI subjects and that the inactivity caused by SCI may be exacerbating this altered sleep pattern.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Ctr Psychobiol & Exercise Res, BR-04020060 São Paulo, Brazil
dc.description.affiliationSanta Casa, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Ctr Psychobiol & Exercise Res, BR-04020060 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent360-366
dc.identifierhttp://dx.doi.org/10.1038/sj.sc.3101971
dc.identifier.citationSpinal Cord. London: Nature Publishing Group, v. 45, n. 5, p. 360-366, 2007.
dc.identifier.doi10.1038/sj.sc.3101971
dc.identifier.issn1362-4393
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29680
dc.identifier.wosWOS:000246307900005
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofSpinal Cord
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectspinal cord injuryen
dc.subjectsleep patternen
dc.subjectlimb movementen
dc.subjectratsen
dc.titleSleep patterns over 15-day period in rats with spinal cord injuryen
dc.typeinfo:eu-repo/semantics/article
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