Immunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiae

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dc.contributor.authorPelizon, Ana Claudia
dc.contributor.authorKaneno, Ramon
dc.contributor.authorSoares, Angela Maria Victoriano de Campos [UNIFESP]
dc.contributor.authorMeira, Domingos Alves [UNIFESP]
dc.contributor.authorSartori, Alexandrina
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-18T11:27:05Z
dc.date.available2018-06-18T11:27:05Z
dc.date.issued2005-01-01
dc.description.abstractIn this study we investigated the effect of beta-glucan derived from Saccharomyces cerevisiae on fungicidal activity, cytokine production and natural killer activity. Spleen and peritoneal cells from female C57BL/6 mice, previously injected (24 or 48 h) with 20 or 100 mu g of glucan by i.p. route, were assayed. In vivo mu-glucan administration primed spleen cells for a higher production of IL-12 and TNF-alpha when S. aureus was used as a stimulus. In addition, beta-glucan increased NK spleen cells activity against YAC target cells. Some immunomodulatory activities not yet described for beta-glucan were observed in this work.en
dc.description.affiliationUniv Fed Sao Paulo, Inst Biosci, Dept Microbiol & Immunol, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Fac Med, Dept Trop Dis & Diagnosis Image, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Inst Biosci, Dept Microbiol & Immunol, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Fac Med, Dept Trop Dis & Diagnosis Image, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent557-564
dc.identifierhttp://www.biomed.cas.cz/physiolres/pdf/54/54_557.pdf
dc.identifier.citationPhysiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 54, n. 5, p. 557-564, 2005.
dc.identifier.issn0862-8408
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45102
dc.identifier.wosWOS:000233101100012
dc.language.isoeng
dc.publisherAcad Sciences Czech Republic, Inst Physiology
dc.relation.ispartofPhysiological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectbeta-glucanen
dc.subjectIL-12en
dc.subjectTNF-alphaen
dc.subjectNK activityen
dc.subjectfungicidal activityen
dc.titleImmunomodulatory activities associated with beta-glucan derived from Saccharomyces cerevisiaeen
dc.typeinfo:eu-repo/semantics/article
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