N-Acetyltransferase 2 genetic polymorphisms and risk of colorectal cancer

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dc.contributor.authorSilva, Tiago Donizetti da [UNIFESP]
dc.contributor.authorFelipe, Aledson Vitor [UNIFESP]
dc.contributor.authorLima, Jacqueline Miranda de [UNIFESP]
dc.contributor.authorOshima, Celina Tizuko Fujiyama [UNIFESP]
dc.contributor.authorForones, Nora Manoukian [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:11Z
dc.date.available2016-01-24T14:06:11Z
dc.date.issued2011-02-14
dc.description.abstractAIM: To investigate the possible association between meat intake, cigarette smoking and N-acetyltransferase 2 (NAT2) genetic polymorphisms on colorectal cancer (CRC) risk.METHODS: Patients with CRC were matched for gender and age to healthy controls. Meat intake and cigarette smoking were assessed using a specific frequency questionnaire. DNA was extracted from peripheral blood and the genotypes of the polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism. Five NAT2 alleles were studied (WT, M1, M2, M3 and M4) using specific digestion enzymes.RESULTS: A total of 147 patients with colorectal cancer (76 women and 90 men with colon cancer) and 212 controls were studied. the mean age of the two groups was 62 years. More than half the subjects (59.8% in the case group and 51.9% in the control group) were NAT2 slow acetylators. the odds ratio for colorectal cancer was 1.38 (95% CI: 0.90-2.12) in slow acetylators. Although the number of women was small (n = 76 in the case group), the cancer risk was found to be lower in intermediate (W/Mx) acetylators [odds ratio (OR): 0.55, 95% confidence interval (95% CI): 0.29-1.02]. This difference was not observed in men (OR: 0.56, 95% CI: 0.16-2.00). Among NAT2 fast acetylators (W/W or W/Mx), meat consumption more than 3 times a week increased the risk of colorectal cancer (OR: 2.05, 95% CI: 1.01-4.16). in contrast, cigarette smoking increased the risk of CRC among slow acetylators (OR: 1.97, 95% CI: 1.02-3.79).CONCLUSION: the risk of CRC was higher among fast acetylators who reported a higher meat intake. Slow NAT2 acetylation was associated with an increased risk of CRC. (C) 2011 Baishideng. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Div Gastroenterol, Oncol Grp, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Gastroenterol, Oncol Grp, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent760-765
dc.identifierhttp://dx.doi.org/10.3748/wjg.v17.i6.760
dc.identifier.citationWorld Journal of Gastroenterology. Beijing: Baishideng Publ Grp Co Ltd, v. 17, n. 6, p. 760-765, 2011.
dc.identifier.doi10.3748/wjg.v17.i6.760
dc.identifier.issn1007-9327
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33465
dc.identifier.wosWOS:000288058700010
dc.language.isoeng
dc.publisherBaishideng Publ Grp Co Ltd
dc.relation.ispartofWorld Journal of Gastroenterology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectN-acetyltransferase 2en
dc.subjectPolymorphismen
dc.subjectColorectal canceren
dc.titleN-Acetyltransferase 2 genetic polymorphisms and risk of colorectal canceren
dc.typeinfo:eu-repo/semantics/article
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