EFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONE

dc.contributor.authorGil, Frida Zaladek [UNIFESP]
dc.contributor.authorSilva, VLC
dc.contributor.authorCavanal, Maria de Fátima [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:05:05Z
dc.date.available2018-06-15T17:05:05Z
dc.date.issued1991-10-01
dc.description.abstract1. The influence of thyroparathyroidectomy and/or acidosis on renal function and specifically on acid excretion was studied in rats treated with a cumulative dose of 2 mg of aluminium.2. Aluminium-treated and non-treated thyroparathyroidectomized rats showed a significant decrease in glomerular filtration rate and in the urinary/plasma inulin ratio without alteration in net acid excretion.3. Non-treated thyroparathyroidectomized acidotic rats showed a significant fall in the amount of ammonium excreted and in overall acid excretion, suggesting that parathyroid hormone participates in an important way in the defence against metabolic acidosis.4. The effects of acidosis, thyroparathyroidectomy and aluminium treatment on renal function parameters were not additive, suggesting a common final mechanism. In normal or acidotic aluminium-treated rats, thyroparathyroidectomy had no effect on renal acid excretion, suggesting that aluminium even in low doses inhibited the action of PTH on the renal tubule.5. After exposure to aluminium, the relative inhibition of PTH on the renal tubule may become an additional factor that could contribute to the worsening of clinical conditions in which an inappropriate retention of acid loads can occur.en
dc.description.affiliationESCOLA PAULISTA MED SCH,DEPT FISIOL,DISCIPLINA FISIOL RENAL & TERMOMETABOL,BR-04023 SAO PAULO,BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED SCH,DEPT FISIOL,DISCIPLINA FISIOL RENAL & TERMOMETABOL,BR-04023 SAO PAULO,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent465-470
dc.identifierhttp://dx.doi.org/10.1042/cs0810465
dc.identifier.citationClinical Science. London: Portland Press, v. 81, n. 4, p. 465-470, 1991.
dc.identifier.doi10.1042/cs0810465
dc.identifier.issn0143-5221
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43386
dc.identifier.wosWOS:A1991GJ71300003
dc.language.isoeng
dc.publisherPortland Press
dc.relation.ispartofClinical Science
dc.rightsAcesso aberto
dc.subjectALUMINUMen
dc.subjectMETABOLIC ACIDOSISen
dc.subjectPARATHYROID HORMONEen
dc.subjectRENAL ACID EXCRETIONen
dc.subjectRENAL FUNCTIONen
dc.titleEFFECT OF ALUMINUM ON URINARY ACIDIFICATION IN THE RAT - INFLUENCE OF PARATHYROID-HORMONEen
dc.typeArtigo
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