Family History of Diabetes as a New Determinant of Insulin Sensitivity and Secretion in Patients Who Have Undergone a Simultaneous Pancreas-Kidney Transplant

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dc.contributor.authorRangel, Erika Bevilaqua [UNIFESP]
dc.contributor.authorMelaragno, Cláudio Santiago [UNIFESP]
dc.contributor.authorNeves, Maria Deolinda F. [UNIFESP]
dc.contributor.authorDib, Sergio Atala [UNIFESP]
dc.contributor.authorGonzalez, Adriano Miziara [UNIFESP]
dc.contributor.authorLinhares, Marcelo Moura [UNIFESP]
dc.contributor.authorPacheco-Silva, Alvaro [UNIFESP]
dc.contributor.authorSá, João Roberto de [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:22:31Z
dc.date.available2018-06-15T17:22:31Z
dc.date.issued2010-03-01
dc.description.abstractObjectives: We used homeostasis model assessment to investigate insulin sensitivity and secretion after a simultaneous pancreas-kidney transplant or kidney transplant alone. In that model, fasting plasma glucose and C-peptide levels are used to evaluate insulin sensitivity and beta-cell function.Materials and Methods: Factors (eg, age, sex, race, delayed kidney allograft function) were correlated with homeostasis model assessment of beta-cell function and homeostasis model assessment of insulin sensitivity values after simultaneous pancreas-kidney transplant (n=89) or kidney transplant alone (n=68), and the results were compared with those in healthy subjects (n=49).Results: Homeostasis model assessment of beta-cell function values were similar in patients who underwent kidney transplant alone or a simultaneous pancreas-kidney transplant, and were higher than homeostasis model assessment of beta-cell function values in healthy subjects. The homeostasis model assessment of insulin sensitivity showed intermediate values for patients who underwent a simultaneous pancreas-kidney transplant and correlated with prednisone dosages (in those who underwent kidney transplant alone) and tacrolimus levels (in patients who underwent a simultaneous pancreas-kidney transplant). Homeostasis model assessment of beta-cell function values correlated with prednisone dosages in both groups and with tacrolimus levels in only those who underwent a simultaneous pancreas-kidney transplant. The body mass index of subjects who underwent kidney transplant alone correlated with both homeostasis model assessment of beta-cell function results and homeostasis model assessment of insulin sensitivity results. A family history of diabetes in subjects who underwent a simultaneous pancreas-kidney transplant correlated with homeostasis model assessment of beta-cell function results and homeostasis model assessment of insulin sensitivity results.Conclusions: Immunosuppressive regimen and body mass index were linked with reduced insulin sensitivity after kidney transplant. A family history of diabetes was linked with higher values of insulin secretion and lower insulin sensitivity in patients who underwent a simultaneous pancreas-kidney transplant.en
dc.description.affiliationUniv Fed Sao Paulo, Div Nephrol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Div Endocrinol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Surg, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Nephrol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Div Endocrinol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Surg, BR-04023900 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent29-37
dc.identifierhttp://www.ectrx.org/forms/ectrxcontentshow.php?doi_id=&year=2010&volume=8&issue=1&supplement=0&makale_no=0&spage_number=29&content_type=FULL%20TEXT
dc.identifier.citationExperimental And Clinical Transplantation. Ankara: Baskent Univ, v. 8, n. 1, p. 29-37, 2010.
dc.identifier.issn1304-0855
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43640
dc.identifier.wosWOS:000276423000006
dc.language.isoeng
dc.publisherBaskent Univ
dc.relation.ispartofExperimental And Clinical Transplantation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHOMAen
dc.subjectInsulin secretionen
dc.subjectInsulin sensitivityen
dc.subjectPancreas transplanten
dc.titleFamily History of Diabetes as a New Determinant of Insulin Sensitivity and Secretion in Patients Who Have Undergone a Simultaneous Pancreas-Kidney Transplanten
dc.typeinfo:eu-repo/semantics/article
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