Mortality Profile Related to Systemic Lupus Erythematosus: A Multiple Cause-of-death Analysis

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dc.contributor.authorSouza, Deborah C. C. [UNIFESP]
dc.contributor.authorSanto, Augusto H. [UNIFESP]
dc.contributor.authorSato, Emilia I. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:26:58Z
dc.date.available2016-01-24T14:26:58Z
dc.date.issued2012-03-01
dc.description.abstractObjective. To analyze the mortality profile related to systemic lupus erythematosus (SLE) in the state of São Paulo, Brazil.Methods. for the 1985-2007 period, we analyzed all death certificates (n = 4815) on which SLE was listed as an underlying (n = 3133) or non-underlying (n = 1682) cause of death. We evaluated sex, age, and the causes of death, comparing the first and last 5 years of the period, as well as determining the observed/expected death ratio (O/E ratio).Results. for SLE as an underlying cause, the mean age at death was 35.77 years (SD 15.12) and the main non-underlying causes of death were renal failure, circulatory system diseases, pneumonia, and septicemia. Over the period, the proportional mention of infectious causes and circulatory system diseases increased, whereas renal diseases decreased. for SLE as a non-underlying cause of death, the most common underlying causes of death were circulatory, respiratory, genitourinary, and digestive system diseases, and certain infections. the overall death O/E ratio was > 1 for renal failure, tuberculosis, septicemia, pneumonia, and digestive system diseases, as well as for circulatory system diseases at < 50 years of age, particularly acute myocardial infarct.Conclusion. Unlike in developed countries, renal failure and infectious diseases are still the most frequent causes of death. the increase in SLE deaths associated with infection, especially pneumonia and septicemia, is worrisome. the judicious use of immunosuppressive therapy together with vigorous treatment of cardiovascular comorbidities is crucial to the successful management of SLE and to improving survival of patients with SLE. (First Release Jan 15 2012; J Rheumatol 2012;39:496-503; doi:10.3899/jrheum.110241)en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Fac Saude Publ, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Fac Saude Publ, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent496-503
dc.identifierhttp://dx.doi.org/10.3899/jrheum.110241
dc.identifier.citationJournal of Rheumatology. Toronto: J Rheumatol Publ Co, v. 39, n. 3, p. 496-503, 2012.
dc.identifier.doi10.3899/jrheum.110241
dc.identifier.issn0315-162X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34702
dc.identifier.wosWOS:000302038800009
dc.language.isoeng
dc.publisherJ Rheumatol Publ Co
dc.relation.ispartofJournal of Rheumatology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMULTIFACTORIAL CAUSALITYen
dc.subjectCAUSES of DEATHen
dc.subjectSLE MORTALITY TRENDSen
dc.subjectMORTALITYen
dc.subjectSYSTEMIC LUPUS ERYTHEMATOSUSen
dc.subjectVITAL STATISTICSen
dc.titleMortality Profile Related to Systemic Lupus Erythematosus: A Multiple Cause-of-death Analysisen
dc.typeinfo:eu-repo/semantics/article
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