AGE-RELATED ANTICONVULSANT ACTIVITY of NMDA in the RAT CAUDATE-PUTAMEN

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1992-06-19
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Cavalheiro, E. A.
Defeo, M. R.
Mecarelli, O.
Ricci, G.
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Striatal pathways are important for modulating the threshold for seizures in the rat forebrain. N-Methyl-D-aspartate (NMDA), an excitatory amino acid derivative and powerful anticonvulsant agent, when injected into the brain, has been shown to protect adult rats against kindling and pilocarpine-induced seizures when injected into the caudate-putamen. the present study examines whether the anticonvulsant action of NMDA in the caudate-putamen varies with age. Bilateral striatal administration of NMDA was effective in suppressing bicuculline-induced seizures in rats older than 23 days of age. the results suggest that striatal pathways involved in the anticonvulsant activity of NMDA in the caudate-putamen are not functionally active in developing rats before the 4th week of life.
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Developmental Brain Research. Amsterdam: Elsevier B.V., v. 67, n. 2, p. 371-374, 1992.
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