AGE-RELATED ANTICONVULSANT ACTIVITY of NMDA in the RAT CAUDATE-PUTAMEN
Data
1992-06-19
Tipo
Artigo
Título da Revista
ISSN da Revista
Título de Volume
Resumo
Striatal pathways are important for modulating the threshold for seizures in the rat forebrain. N-Methyl-D-aspartate (NMDA), an excitatory amino acid derivative and powerful anticonvulsant agent, when injected into the brain, has been shown to protect adult rats against kindling and pilocarpine-induced seizures when injected into the caudate-putamen. the present study examines whether the anticonvulsant action of NMDA in the caudate-putamen varies with age. Bilateral striatal administration of NMDA was effective in suppressing bicuculline-induced seizures in rats older than 23 days of age. the results suggest that striatal pathways involved in the anticonvulsant activity of NMDA in the caudate-putamen are not functionally active in developing rats before the 4th week of life.
Descrição
Citação
Developmental Brain Research. Amsterdam: Elsevier B.V., v. 67, n. 2, p. 371-374, 1992.