The Place of protease inhibitors in antiretroviral treatment

dc.contributor.authorTenore, Simone de Barros [UNIFESP]
dc.contributor.authorFerreira, P.r.a. [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:41:14Z
dc.date.available2015-06-14T13:41:14Z
dc.date.issued2009-10-01
dc.description.abstractWith the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and ritonavir-boosted protease inhibitors. Both are proven to control viral replication and lead to immunological gain. The choice between a non-nucleoside analog reverse transcriptase inhibitor and a protease inhibitor as a third antiretroviral drug in the therapy should consider factors related to the individual, as well as the inclusion of the best therapy in the patient's daily activities and potential adherence. The protease inhibitor-based therapies showed similar efficacy among the various inhibitors with characteristics concerning the adverse events from each medicine. For the treatment of protease-resistant patients, darunavir and tipranavir showed good efficacy with higher genetic barrier to resistance.en
dc.description.affiliationFederal University of São Paulo
dc.description.affiliationUnifespUNIFESP, EPM
dc.description.sourceSciELO
dc.format.extent371-374
dc.identifierhttp://dx.doi.org/10.1590/S1413-86702009000500012
dc.identifier.citationBrazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 13, n. 5, p. 371-374, 2009.
dc.identifier.doi10.1590/S1413-86702009000500012
dc.identifier.fileS1413-86702009000500012.pdf
dc.identifier.issn1413-8670
dc.identifier.scieloS1413-86702009000500012
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/5314
dc.identifier.wosWOS:000277559300012
dc.language.isoeng
dc.publisherBrazilian Society of Infectious Diseases
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsAcesso aberto
dc.subjectAIDSen
dc.subjectantiretroviral treatmenten
dc.subjectprotease inhibitorsen
dc.titleThe Place of protease inhibitors in antiretroviral treatmenten
dc.typeArtigo
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