The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

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dc.contributor.authorRazavi, H.
dc.contributor.authorWaked, I.
dc.contributor.authorSarrazin, C.
dc.contributor.authorMyers, R. P.
dc.contributor.authorIdilman, R.
dc.contributor.authorCalinas, F.
dc.contributor.authorVogel, W.
dc.contributor.authorMendes Correa, M. C.
dc.contributor.authorHezode, C.
dc.contributor.authorLazaro, P.
dc.contributor.authorAkarca, U.
dc.contributor.authorAleman, S.
dc.contributor.authorBalik, I.
dc.contributor.authorBerg, T.
dc.contributor.authorBihl, F.
dc.contributor.authorBilodeau, M.
dc.contributor.authorBlasco, A. J.
dc.contributor.authorBrandao Mello, C. E.
dc.contributor.authorBruggmann, P.
dc.contributor.authorButi, M.
dc.contributor.authorCalleja, J. L.
dc.contributor.authorCheinquer, H.
dc.contributor.authorChristensen, P. B.
dc.contributor.authorClausen, M.
dc.contributor.authorCoelho, H. S. M.
dc.contributor.authorCramp, M. E.
dc.contributor.authorDore, G. J.
dc.contributor.authorDoss, W.
dc.contributor.authorDuberg, A. S.
dc.contributor.authorEl-Sayed, M. H.
dc.contributor.authorErgor, G.
dc.contributor.authorEsmat, G.
dc.contributor.authorFalconer, K.
dc.contributor.authorFelix, J.
dc.contributor.authorFerraz, Maria Lucia Gomes [UNIFESP]
dc.contributor.authorFerreira, Paulo Roberto [UNIFESP]
dc.contributor.authorFrankova, S.
dc.contributor.authorGarcia-Samaniego, J.
dc.contributor.authorGerstoft, J.
dc.contributor.authorGiria, J. A.
dc.contributor.authorGoncales, F. L.
dc.contributor.authorGower, E.
dc.contributor.authorGschwantler, M.
dc.contributor.authorGuimaraes Pessoa, M.
dc.contributor.authorHindman, S. J.
dc.contributor.authorHofer, H.
dc.contributor.authorHusa, P.
dc.contributor.authorKaberg, M.
dc.contributor.authorKaita, K. D. E.
dc.contributor.authorKautz, A.
dc.contributor.authorKaymakoglu, S.
dc.contributor.authorKrajden, M.
dc.contributor.authorKrarup, H.
dc.contributor.authorLaleman, W.
dc.contributor.authorLavanchy, D.
dc.contributor.authorMarinho, R. T.
dc.contributor.authorMarotta, P.
dc.contributor.authorMauss, S.
dc.contributor.authorMoreno, C.
dc.contributor.authorMurphy, K.
dc.contributor.authorNegro, F.
dc.contributor.authorNemecek, V.
dc.contributor.authorOrmeci, N.
dc.contributor.authorOvrehus, A. L. H.
dc.contributor.authorParkes, J.
dc.contributor.authorPasini, K.
dc.contributor.authorPeltekian, K. M.
dc.contributor.authorRamji, A.
dc.contributor.authorReis, N.
dc.contributor.authorRoberts, S. K.
dc.contributor.authorRosenberg, W. M.
dc.contributor.authorRoudot-Thoraval, F.
dc.contributor.authorRyder, S. D.
dc.contributor.authorSarmento-Castro, R.
dc.contributor.authorSemela, D.
dc.contributor.authorSherman, M.
dc.contributor.authorShiha, G. E.
dc.contributor.authorSievert, W.
dc.contributor.authorSperl, J.
dc.contributor.authorStarkel, P.
dc.contributor.authorStauber, R. E.
dc.contributor.authorThompson, A. J.
dc.contributor.authorUrbanek, P.
dc.contributor.authorVan Damme, P.
dc.contributor.authorvan Thiel, I.
dc.contributor.authorVan Vlierberghe, H.
dc.contributor.authorVandijck, D.
dc.contributor.authorWedemeyer, H.
dc.contributor.authorWeis, N.
dc.contributor.authorWiegand, J.
dc.contributor.authorYosry, A.
dc.contributor.authorZekry, A.
dc.contributor.authorCornberg, M.
dc.contributor.authorMuellhaupt, B.
dc.contributor.authorEstes, C.
dc.contributor.institutionCtr Dis Anal
dc.contributor.institutionNatl Liver Inst
dc.contributor.institutionJW Goethe Univ Hosp
dc.contributor.institutionUniv Calgary
dc.contributor.institutionAnkara Univ
dc.contributor.institutionHosp Santo Antonio Capuchos
dc.contributor.institutionMed Univ Innsbruck
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHop Henri Mondor
dc.contributor.institutionAdv Tech Hlth Serv Res TAISS
dc.contributor.institutionEge Univ
dc.contributor.institutionKarolinska Inst
dc.contributor.institutionKarolinska Univ Hosp
dc.contributor.institutionUniv Leipzig
dc.contributor.institutionOsped Cantonale
dc.contributor.institutionUniv Montreal
dc.contributor.institutionFed Univ State Rio de Janeiro
dc.contributor.institutionArud Ctr Addict Med
dc.contributor.institutionHosp Valle de Hebron
dc.contributor.institutionHosp Puerta Hierro
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.contributor.institutionOdense Univ Hosp
dc.contributor.institutionReg Hosp Hovedstaden
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniv Plymouth
dc.contributor.institutionUniv New S Wales
dc.contributor.institutionCairo Univ
dc.contributor.institutionOrebro Univ Hosp
dc.contributor.institutionUniv Orebro
dc.contributor.institutionAin Shams Univ
dc.contributor.institutionDokuz Eylul Univ
dc.contributor.institutionExigo Consultores
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Clin & Expt Med
dc.contributor.institutionHosp Carlos III
dc.contributor.institutionUniv Copenhagen
dc.contributor.institutionDireccao Geral Saude
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionWilhelminenspital Stadt Wien
dc.contributor.institutionMed Univ Vienna
dc.contributor.institutionMasaryk Univ
dc.contributor.institutionUniv Manitoba
dc.contributor.institutionHlth Sci Ctr
dc.contributor.institutionEuropean Liver Patients Assoc
dc.contributor.institutionIstanbul Univ
dc.contributor.institutionUniv British Columbia
dc.contributor.institutionAalborg Univ Hosp
dc.contributor.institutionKatholieke Univ Leuven
dc.contributor.institutionHosp Santa Maria
dc.contributor.institutionUniv Western Ontario
dc.contributor.institutionUniv Dusseldorf
dc.contributor.institutionUniv Libre Brussels
dc.contributor.institutionUniv Hosp
dc.contributor.institutionNatl Inst Publ Hlth
dc.contributor.institutionUniv Southhampton
dc.contributor.institutionDalhousie Univ & Hepatol Serv
dc.contributor.institutionAssembleia Republ
dc.contributor.institutionAlfred Hosp
dc.contributor.institutionMonash Univ
dc.contributor.institutionUCL
dc.contributor.institutionNottingham Univ Hosp NHS Trust
dc.contributor.institutionBiomed Res Unit
dc.contributor.institutionCtr Hosp Porto
dc.contributor.institutionCantonal Hosp St Gallen
dc.contributor.institutionUniv Toronto
dc.contributor.institutionEgyptian Liver Res Inst & Hosp
dc.contributor.institutionMonash Hlth
dc.contributor.institutionCatholic Univ Louvain
dc.contributor.institutionMed Univ Graz
dc.contributor.institutionSt Vincents Hosp
dc.contributor.institutionUniv Melbourne
dc.contributor.institutionCharles Univ Prague
dc.contributor.institutionCent Mil Hosp
dc.contributor.institutionUniv Antwerp
dc.contributor.institutionDeutsch Leberhilfe eV
dc.contributor.institutionGhent Univ Hosp
dc.contributor.institutionUniv Ghent
dc.contributor.institutionHannover Med Sch
dc.contributor.institutionCopenhagen Univ Hosp
dc.contributor.institutionUniv Zurich Hosp
dc.date.accessioned2016-01-24T14:37:09Z
dc.date.available2016-01-24T14:37:09Z
dc.date.issued2014-05-01
dc.description.abstractThe disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. in addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing.en
dc.description.affiliationCtr Dis Anal, Louisville, CO 80027 USA
dc.description.affiliationNatl Liver Inst, Menoufia, Egypt
dc.description.affiliationJW Goethe Univ Hosp, Frankfurt, Germany
dc.description.affiliationUniv Calgary, Liver Unit, Div Gastroenterol & Hepatol, Calgary, AB, Canada
dc.description.affiliationAnkara Univ, Dept Gastroenterol, Sch Med, TR-06100 Ankara, Turkey
dc.description.affiliationHosp Santo Antonio Capuchos, Dept Gastroenterol, Ctr Hosp Lisboa Cent, Lisbon, Portugal
dc.description.affiliationMed Univ Innsbruck, A-6020 Innsbruck, Austria
dc.description.affiliationUniv São Paulo, Sch Med, São Paulo, Brazil
dc.description.affiliationHop Henri Mondor, Serv Hepatogastroenterol, F-94010 Creteil, France
dc.description.affiliationAdv Tech Hlth Serv Res TAISS, Madrid, Spain
dc.description.affiliationEge Univ, Izmir, Turkey
dc.description.affiliationKarolinska Inst, Dept Med Huddinge, Stockholm, Sweden
dc.description.affiliationKarolinska Univ Hosp, Dept Gastroenterol & Hepatol Infect Dis, Stockholm, Sweden
dc.description.affiliationAnkara Univ, TR-06100 Ankara, Turkey
dc.description.affiliationUniv Leipzig, D-04109 Leipzig, Germany
dc.description.affiliationOsped Cantonale, Dept Gastroenterol, Bellinzona, Switzerland
dc.description.affiliationUniv Montreal, Dept Med, Liver Unit, Montreal, PQ H3C 3J7, Canada
dc.description.affiliationFed Univ State Rio de Janeiro, Dept Gastroenterol, Rio de Janeiro, Brazil
dc.description.affiliationArud Ctr Addict Med, Zurich, Switzerland
dc.description.affiliationHosp Valle de Hebron, CIBERehd, Barcelona, Spain
dc.description.affiliationHosp Puerta Hierro, Madrid, Spain
dc.description.affiliationUniv Fed Rio Grande do Sul, Hosp Clin, Porto Alegre, RS, Brazil
dc.description.affiliationOdense Univ Hosp, Dept Infect Dis, DK-5000 Odense, Denmark
dc.description.affiliationReg Hosp Hovedstaden, Copenhagen, Denmark
dc.description.affiliationUniv Fed Rio de Janeiro, Dept Clin Med, Rio de Janeiro, Brazil
dc.description.affiliationUniv Plymouth, Peninsula Sch Med & Dent, Plymouth PL4 8AA, Devon, England
dc.description.affiliationUniv New S Wales, Kirby Inst, Sydney, NSW, Australia
dc.description.affiliationCairo Univ, Cairo, Egypt
dc.description.affiliationOrebro Univ Hosp, Dept Infect Dis, Orebro, Sweden
dc.description.affiliationUniv Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden
dc.description.affiliationAin Shams Univ, Cairo, Egypt
dc.description.affiliationDokuz Eylul Univ, Izmir, Turkey
dc.description.affiliationKarolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Infect Dis Unit, Stockholm, Sweden
dc.description.affiliationExigo Consultores, Alhos Vedros, Portugal
dc.description.affiliationUniversidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationInst Clin & Expt Med, Dept Hepatogastroenterol, Prague, Czech Republic
dc.description.affiliationHosp Carlos III, CIBERehd, Madrid, Spain
dc.description.affiliationUniv Copenhagen, Copenhagen, Denmark
dc.description.affiliationDireccao Geral Saude, Lisbon, Portugal
dc.description.affiliationUniv Estadual Campinas, Disciplina Doencas Infecciosas, Dept Clin Med, Grp Estudo Hepatites,Fac Ciencias Med,UNICAMP, São Paulo, Brazil
dc.description.affiliationWilhelminenspital Stadt Wien, Dept Internal Med 4, Vienna, Austria
dc.description.affiliationUniv São Paulo, Sch Med, Div Gastroenterol & Hepatol, São Paulo, Brazil
dc.description.affiliationMed Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Vienna, Austria
dc.description.affiliationMasaryk Univ, Univ Hosp Brno, Clin Infect Dis, Brno, Czech Republic
dc.description.affiliationUniv Manitoba, Dept Internal Med, Sect Hepatol, Winnipeg, MB, Canada
dc.description.affiliationHlth Sci Ctr, Viral Hepatitis Invest Unit, Winnipeg, MB, Canada
dc.description.affiliationEuropean Liver Patients Assoc, St Truiden, Belgium
dc.description.affiliationIstanbul Univ, Istanbul, Turkey
dc.description.affiliationUniv British Columbia, British Columbia Ctr Dis Control, Vancouver, BC V5Z 1M9, Canada
dc.description.affiliationAalborg Univ Hosp, Dept Med Gastroenterol, Aalborg, Denmark
dc.description.affiliationAalborg Univ Hosp, Sect Mol Diagnost, Aalborg, Denmark
dc.description.affiliationKatholieke Univ Leuven, Univ Hosp Leuven, Louvain, Belgium
dc.description.affiliationHosp Santa Maria, Dept Gastroenterol, Ctr Hosp Lisboa Norte, Lisbon, Portugal
dc.description.affiliationUniv Western Ontario, Div Gastroenterol, London, ON, Canada
dc.description.affiliationUniv Dusseldorf, Dusseldorf, Germany
dc.description.affiliationUniv Libre Brussels, Erasme Univ Hosp, Brussels, Belgium
dc.description.affiliationUniv Hosp, Div Gastroenterol & Hepatol, Geneva, Switzerland
dc.description.affiliationUniv Hosp, Div Clin Pathol, Geneva, Switzerland
dc.description.affiliationNatl Inst Publ Hlth, Natl Reference Lab Hepatitis, Prague, Czech Republic
dc.description.affiliationUniv Southhampton, Southampton, England
dc.description.affiliationDalhousie Univ & Hepatol Serv, Capital Dist Hlth Author, Queen Elizabeth II Hlth Sci Ctr, Dept Med, Halifax, NS, Canada
dc.description.affiliationDalhousie Univ & Hepatol Serv, Capital Dist Hlth Author, Queen Elizabeth II Hlth Sci Ctr, Dept Surg, Halifax, NS, Canada
dc.description.affiliationUniv British Columbia, Dept Gastroenterol, Vancouver, BC V5Z 1M9, Canada
dc.description.affiliationAssembleia Republ, Lisbon, Portugal
dc.description.affiliationAlfred Hosp, Melbourne, Vic, Australia
dc.description.affiliationMonash Univ, Melbourne, Vic 3004, Australia
dc.description.affiliationUCL, Div Med, UCL Inst Liver & Digest Hlth, London, England
dc.description.affiliationHop Henri Mondor, Dept Sante Publ, F-94010 Creteil, France
dc.description.affiliationNottingham Univ Hosp NHS Trust, Nottingham, England
dc.description.affiliationBiomed Res Unit, Nottingham, England
dc.description.affiliationCtr Hosp Porto, Dept Infect Dis, Oporto, Portugal
dc.description.affiliationCantonal Hosp St Gallen, Div Gastroenterol & Hepatol, St Gallen, Switzerland
dc.description.affiliationUniv Toronto, Toronto Gen Hosp, Univ Hlth Network, Toronto, ON M5G 1L7, Canada
dc.description.affiliationEgyptian Liver Res Inst & Hosp, Dakahliah, Egypt
dc.description.affiliationMonash Hlth, Melbourne, Vic, Australia
dc.description.affiliationCatholic Univ Louvain, Clin Univ St Luc, Brussels, Belgium
dc.description.affiliationMed Univ Graz, Div Gastroenterol & Hepatol, Dept Internal Med, Graz, Austria
dc.description.affiliationSt Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, Australia
dc.description.affiliationUniv Melbourne, Melbourne, Vic, Australia
dc.description.affiliationCharles Univ Prague, Dept Internal Med, Fac Med 1, Prague, Czech Republic
dc.description.affiliationCent Mil Hosp, Prague, Czech Republic
dc.description.affiliationUniv Antwerp, B-2020 Antwerp, Belgium
dc.description.affiliationDeutsch Leberhilfe eV, Cologne, Germany
dc.description.affiliationGhent Univ Hosp, Ghent, Belgium
dc.description.affiliationUniv Ghent, Belgium Hasselt Univ, Dept Hlth Econ & Patient Safety, Diepenbeek, Belgium
dc.description.affiliationHannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany
dc.description.affiliationCopenhagen Univ Hosp, Hvidovre, Denmark
dc.description.affiliationUniv New S Wales, St George Hosp Clin Sch Med, Sydney, NSW, Australia
dc.description.affiliationUniv New S Wales, Sch Med Sci, Sydney, NSW, Australia
dc.description.affiliationUniv Zurich Hosp, Swiss HPB Hepatopancreatobiliary Ctr, CH-8091 Zurich, Switzerland
dc.description.affiliationUniv Zurich Hosp, Dept Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipGilead Sciences
dc.format.extent34-59
dc.identifierhttp://dx.doi.org/10.1111/jvh.12248
dc.identifier.citationJournal of Viral Hepatitis. Hoboken: Wiley-Blackwell, v. 21, p. 34-59, 2014.
dc.identifier.doi10.1111/jvh.12248
dc.identifier.issn1352-0504
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37688
dc.identifier.wosWOS:000333893200003
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Viral Hepatitis
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectHCVen
dc.subjectdiagnosisen
dc.subjecttreatmenten
dc.subjecthepatitis Cen
dc.subjectprevalenceen
dc.subjectepidemiologyen
dc.subjectdisease burdenen
dc.subjectmortalityen
dc.subjectincidenceen
dc.titleThe present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigmen
dc.typeinfo:eu-repo/semantics/article
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