Neonatal exposure to constant light prevents anhedonia-like behavior induced by constant light exposure in adulthood

Página do item simplificado
dc.contributor.authorMartynhak, Bruno J.
dc.contributor.authorCorreia, Diego
dc.contributor.authorMorais, Livia H.
dc.contributor.authorAraujo, Paula [UNIFESP]
dc.contributor.authorAndersen, Monica L. [UNIFESP]
dc.contributor.authorLima, Marcelo M. S.
dc.contributor.authorLouzada, Fernando M.
dc.contributor.authorAndreatini, Roberto
dc.contributor.institutionUniv Fed Parana
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:17:12Z
dc.date.available2016-01-24T14:17:12Z
dc.date.issued2011-09-12
dc.description.abstractDepressive episodes are associated with disturbances in circadian rhythms, and constant illumination has been reported to induce depressive-like behavior in rodents. Rats kept in constant darkness express the endogenous circadian rhythm, and most animals under constant light conditions lose circadian locomotor rhythmicity. Exposure to constant light in rats during lactation was reported to prevent this loss of circadian rhythm in adulthood. Thus, the aim of the present study was to verify whether exposure to constant light during lactation prevents anhedonia-like behavior induced by constant light in adult rats. in experiment 1, we replicated the anhedonia-like effects of constant light in adult male rats. We showed that this effect is reversed by imipramine treatment in the drinking water. in experiment 2, we subjected rats to constant darkness (neonatal-DD), constant light (neonatal-LL) or to normal light/dark cycle (neonatal-LD) during the neonatal phase and evaluated them after constant light exposure in adulthood. the group exposed to constant light during the neonatal phase did not reduce their sucrose preference and exhibited greater locomotor activity than the other groups. the neonatal-DD group exhibited decreased sucrose preference earlier than controls and had higher serum corticosterone concentrations. Prevention of arrhythymicity might protect neonatal-LL rats from anhedonia-like behavior induced by constant light, whereas constant darkness during the neonatal phase rendered the neonatal-DD group more susceptible to depressive-like behavior. These results corroborate with the literature data indicating that circadian disruption may contribute in mood disorders and that early life stress can influence stress responsivity in adulthood. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Parana, Dept Farmacol, Ctr Politecn, BR-81530900 Curitiba, Parana, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUniv Fed Parana, Dept Fisiol, Ctr Politecn, BR-81530900 Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04024002 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent10-14
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2011.03.022
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 222, n. 1, p. 10-14, 2011.
dc.identifier.doi10.1016/j.bbr.2011.03.022
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34045
dc.identifier.wosWOS:000291418400002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectDepressive behavioren
dc.subjectAnhedoniaen
dc.subjectSucrose preference testen
dc.subjectCircadian rhythmsen
dc.subjectConstant lighten
dc.subjectNeonatal stressen
dc.titleNeonatal exposure to constant light prevents anhedonia-like behavior induced by constant light exposure in adulthooden
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos