T cell receptor excision circles (TRECs) in relation to acute cardiac allograft rejection

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dc.contributor.authorMorgun, Andrey [UNIFESP]
dc.contributor.authorShulzhenko, Natalia [UNIFESP]
dc.contributor.authorSocorro-Silva, Adalberto [UNIFESP]
dc.contributor.authorDiniz, Rosiane Viana Zuza [UNIFESP]
dc.contributor.authorAlmeida, Dirceu Rodrigues de [UNIFESP]
dc.contributor.authorGerbase-Lima, Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:27Z
dc.date.available2016-01-24T12:37:27Z
dc.date.issued2004-11-01
dc.description.abstractThe purpose of this study was to quantify T cell receptor excision circles (TRECs) in blood mononuclear cells of cardiac transplant recipients and to investigate a possible relationship between TREC levels and rejection episodes. in addition, we investigated the correlation of TREC levels with age and also compared the levels between transplant recipients and healthy individuals. TREC levels were assessed by quantitative competitive PCR in 70 blood samples from 27 graft recipients and in 66 blood samples from 66 healthy individuals. the results showed: (1) higher TREC levels during rejection than during rejection-free periods (medians 9.0 vs. 0.3; p<0.001); (2) no suggestion of correlation with doses of prednisone or time after transplantation; (3) a negative correlation between TREC levels and age; and (4) lower TREC levels in cardiac recipients than in age-matched healthy controls. the value of blood TREC level measurements as an approach to rejection monitoring warrants future investigation.en
dc.description.affiliationUNIFESP, Dept Pediat, Div Immunogenet, BR-04024003 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, EPM, Dept Med, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Dept Pediat, Div Immunogenet, BR-04024003 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, EPM, Dept Med, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent612-616
dc.identifierhttps://dx.doi.org/10.1007/s10875-004-6246-1
dc.identifier.citationJournal of Clinical Immunology. New York: Kluwer Academic/plenum Publ, v. 24, n. 6, p. 612-616, 2004.
dc.identifier.doi10.1007/s10875-004-6246-1
dc.identifier.issn0271-9142
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/28000
dc.identifier.wosWOS:000225962800004
dc.language.isoeng
dc.publisherKluwer Academic/plenum Publ
dc.relation.ispartofJournal of Clinical Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectT cell receptor excision circlesen
dc.subjectAcute cardiac rejectionen
dc.subjectNaive T cellsen
dc.subjectTransplantationen
dc.titleT cell receptor excision circles (TRECs) in relation to acute cardiac allograft rejectionen
dc.typeinfo:eu-repo/semantics/article
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