Cytotoxic lignans from the stems of Styrax camporum (Styracaceae)

Página do item simplificado
dc.contributor.authorTeles, H. L.
dc.contributor.authorHemerly, Jefferson Pessoa [UNIFESP]
dc.contributor.authorPauletti, P. M.
dc.contributor.authorPandolfi, JRC
dc.contributor.authorAraujo, A. R.
dc.contributor.authorValentini, SR
dc.contributor.authorYoung, MCM
dc.contributor.authorBolzani, V. D.
dc.contributor.authorSilva, DHS
dc.contributor.institutionUNESP
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInst Bot
dc.date.accessioned2016-01-24T12:37:54Z
dc.date.available2016-01-24T12:37:54Z
dc.date.issued2005-06-01
dc.description.abstractAn ethanolic extract from the stems of Styrax camporum Pohl (Styracaceae), a plant traditionally used for gastrointestinal diseases, was fractionated and subjected to flash chromatography and afforded two benzofuran lignans, egonol and homoegonol, and one furofuran lignan, (+/-) syringaresinol, which were identified by spectral data interpretation. Their cytotoxic activities against Hep-2 (larynx epidermoid carcinoma), HeLa (human cervix carcinoma) and C6 (rat glioma) cell lines were evaluated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay at several concentrations for 24 h. Activities could be observed for egonol against C6 (IC50 = 3.2 mu g/mL) and Hep-2 (IC50 = 3.6 mu g/mL) cell lines, and for homoegonol against C6 (IC50 = 4.9 mu g/mL) and HeLa (IC50 =- 5.3 mu g/mL) cells.en
dc.description.affiliationUNESP, Inst Quim, BR-14800900 Araraquara, Brazil
dc.description.affiliationUNIFESP, Escola Paulista Med, BR-14801902 Araraquara, Brazil
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, Brazil
dc.description.affiliationInst Bot, Secao Fisiol & Bioquim Plantas, BR-01061970 São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP, Escola Paulista Med, EPM
dc.description.sourceWeb of Science
dc.format.extent319-323
dc.identifierhttp://dx.doi.org/10.1080/14786410412331271979
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 19, n. 4, p. 319-323, 2005.
dc.identifier.doi10.1080/14786410412331271979
dc.identifier.issn1478-6419
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28333
dc.identifier.wosWOS:000229394900003
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.subjectStyrax camporumen
dc.subjectStyracaceaeen
dc.subjectcytotoxic lignansen
dc.subjectMTT assayen
dc.titleCytotoxic lignans from the stems of Styrax camporum (Styracaceae)en
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos