Meta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorder

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dc.contributor.authorBloch, Michael H.
dc.contributor.authorLanderos-Weisenberger, Angeli
dc.contributor.authorRosario-Campos, Maria Conceicao do [UNIFESP]
dc.contributor.authorPittenger, Christopher
dc.contributor.authorLeckman, James F.
dc.contributor.institutionYale Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:55Z
dc.date.available2016-01-24T13:51:55Z
dc.date.issued2008-12-01
dc.description.abstractObjective: OCD is a clinically heterogeneous condition. This heterogeneity has the potential to reduce power in genetic, neuroimaging, and clinical trials. Despite a mounting number of studies, there remains debate regarding the exact factor structure of OCD symptoms. the authors conducted a meta-analysis to determine the factor structure of the Yale-Brown Obsessive Compulsive Scale Symptom Checklist.Method: Studies were included if they involved subjects with OCD and included an exploratory factor analysis of the 13 Yale-Brown Obsessive Compulsive Scale Symptom Checklist categories or the items therein. A varimax-rotation was conducted in SAS 9.1 using the PROC FACTOR CORR to extract factors from sample-size weighted co-occurrence matrices. Stratified meta-analysis was conducted to determine the factor structure of OCD in studies involving children and adults separately.Results: Twenty-one studies involving 5,124 participants were included. the four factors generated were 1) symmetry: symmetry obsessions and repeating, ordering, and counting compulsions; 2) forbidden thoughts: aggression, sexual, religious, and somatic obsessions and checking compulsions, 3) cleaning: cleaning and contamination, and 4) hoarding: hoarding obsessions and compulsions. Factor analysis of studies including adults yielded an identical factor structure compared to the overall meta-analysis. Factor analysis of child-only studies differed in that checking loaded highest on the symmetry factor and somatic obsessions, on the cleaning factor.Conclusions: A four-factor structure explained a large proportion of the heterogeneity in the clinical symptoms of OCD. Further item-level factor analyses are needed to determine the appropriate placement of miscellaneous somatic and checking OCD symptoms.en
dc.description.affiliationYale Univ, Ctr Child Study, TS OCD Clin, Sch Med, New Haven, CT 06520 USA
dc.description.affiliationYale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, Dept Psychiat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNIMH
dc.description.sponsorshipNIH Loan Repayment Program
dc.description.sponsorshipTourette's Syndrome Association
dc.description.sponsorshipDoris Duke Charitable Foundation
dc.description.sponsorshipAPA/Janssen Research Scholars Program
dc.description.sponsorshipAA-CAP Pilot Research
dc.description.sponsorshipAPA/NIMH PMRTP
dc.description.sponsorshipIDNIMH: K05 MH-076273
dc.format.extent1532-1542
dc.identifierhttp://dx.doi.org/10.1176/appi.ajp.2008.08020320
dc.identifier.citationAmerican Journal of Psychiatry. Arlington: Amer Psychiatric Publishing, Inc, v. 165, n. 12, p. 1532-1542, 2008.
dc.identifier.doi10.1176/appi.ajp.2008.08020320
dc.identifier.issn0002-953X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31058
dc.identifier.wosWOS:000261266000010
dc.language.isoeng
dc.publisherAmer Psychiatric Publishing, Inc
dc.relation.ispartofAmerican Journal of Psychiatry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleMeta-Analysis of the Symptom Structure of Obsessive-Compulsive Disorderen
dc.typeinfo:eu-repo/semantics/article
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