Ultrastructural features of the myotendinous junction of the sternomastoid muscle in Wistar rats: From newborn to aging

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dc.contributor.authorCiena, Adriano Polican
dc.contributor.authorYokomizo de Almeida, Sonia Regina
dc.contributor.authorBolina, Cristina de Sousa
dc.contributor.authorBolina-Matos, Regina de Sousa
dc.contributor.authorGrassi Rici, Rose Eli
dc.contributor.authorPereira Da Silva, Marcelo Cavenaghi [UNIFESP]
dc.contributor.authorMiglino, Maria Angelica
dc.contributor.authorWatanabe, Ii-Sei
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:36Z
dc.date.available2016-01-24T14:27:36Z
dc.date.issued2012-09-01
dc.description.abstractThe myotendinous junction (MTJ) is a major area for transmitting force from the skeletal muscle system and acts in joint position and stabilization. This study aimed to use transmission electron microscopy to describe the ultrastructural features of the MTJ of the sternomastoid muscle in Wistar rats from newborn to formation during adulthood and possible changes with aging. Ultrastructural features of the MTJ from the newborn group revealed pattern during development with interactions between muscle cells and extracellular matrix elements with thin folds in the sarcolemma and high cellular activity evidenced through numerous oval mitochondria groupings. the adult group had classical morphological features of the MTJ, with folds in the sarcolemma forming long projections called finger-like processes and sarcoplasmic invaginations. Sarcomeres were aligned in series, showing mitochondria near the Z line in groupings between collagen fiber bundles. the old group had altered finger-like processes, thickened in both levels of sarcoplasmic invaginations and in central connections with the lateral junctions. We conclude that the MTJ undergoes intense activity from newborn to its formation during adulthood. With increasing age, changes to the MTJ were observed in the shapes of the invaginations and finger-like processes due to hypoactivity, potentially compromising force transmission and joint stability. Microsc. Res. Tech. 75:12921296, 2012. (C) 2012 Wiley Periodicals, Inc.en
dc.description.affiliationUniv São Paulo, Dept Anat, Inst Biomed Sci ICB III, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Vet Med & Anim Sci, Dept Surg, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Morphology and Genetic, Federal University of São Paulo, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1292-1296
dc.identifierhttp://dx.doi.org/10.1002/jemt.22063
dc.identifier.citationMicroscopy Research and Technique. Hoboken: Wiley-Blackwell, v. 75, n. 9, p. 1292-1296, 2012.
dc.identifier.doi10.1002/jemt.22063
dc.identifier.issn1059-910X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35201
dc.identifier.wosWOS:000307961900021
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMicroscopy Research and Technique
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectmyotendinous junctionen
dc.subjectdevelopmenten
dc.subjectmuscleen
dc.subjectskeletalen
dc.subjectagingen
dc.subjecttransmission electron microscopyen
dc.titleUltrastructural features of the myotendinous junction of the sternomastoid muscle in Wistar rats: From newborn to agingen
dc.typeinfo:eu-repo/semantics/article
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