Sulfated glycosaminoglycans of the vagina and perineal skin in pre- and postmenopausal women, according to genital prolapse stage

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dc.contributor.authorBezerra, LRPS
dc.contributor.authorFeldner, P. C.
dc.contributor.authorKati, L. M.
dc.contributor.authorGirao, MJBC
dc.contributor.authorSartori, M. G.
dc.contributor.authorBaracat, E. C.
dc.contributor.authorLima, G. R. de
dc.contributor.authorNader, H. B.
dc.contributor.authorDietrich, C. P.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:17Z
dc.date.available2016-01-24T12:37:17Z
dc.date.issued2004-08-01
dc.description.abstractThe aim of this study was to analyze the amount and types of sulfated glycosaminoglycans (GAGs) of the extracellular matrix (ECM) in the posterior vaginal wall and perineal skin in menacme and postmenopausal women, according to genital prolapse stage. Samples of vaginal tissue and perineal skin were obtained from 40 women who underwent vaginal surgery. Sulfated glycosaminoglycans were extracted by extensive tissue maxatase digestion, submitted to electrophoresis on agarose gel, and their concentrations were determined by densitometry. Dermatan sulphate (DS) was the predominant GAG, followed by chondroitin sulfate (CS) and heparan sulfate (HS). in the vagina there was a significant decrease in total GAGs, CS, DS and HS in postmenopausal women with prolapse stage 2 and 3 compared to the premenopausal group, independent of the stage. in stage 2 and 3 postmenopausal patients there was a significant decrease of DS and HS compared to the stage 1 postmenopausal group. in perineal skin there was no significant difference between total GAG amount, DS and HS. However, the amount of CS in premenopausal stage 1 patients was significantly than that in postmenopausal patients stage 1 and stages 2 and 3. in conclusions, there are quantitative and qualitative differences in GAGs of the ECM in vaginal wall and perineal skin between women in menacme and the postmenopause, according to genital prolapse stage.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Gynecol, Sect Urogynecol & Pelv Surg, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biochem, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Gynecol, Sect Urogynecol & Pelv Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biochem, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent266-271
dc.identifierhttp://dx.doi.org/10.1007/s00192-004-1150-z
dc.identifier.citationInternational Urogynecology Journal. Godalming: Springer London Ltd, v. 15, n. 4, p. 266-271, 2004.
dc.identifier.doi10.1007/s00192-004-1150-z
dc.identifier.issn0937-3462
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27848
dc.identifier.wosWOS:000222863500010
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofInternational Urogynecology Journal
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectextracellular matrixen
dc.subjectgenital prolapseen
dc.subjectglycosaminoglycansen
dc.subjectpostmenopauseen
dc.titleSulfated glycosaminoglycans of the vagina and perineal skin in pre- and postmenopausal women, according to genital prolapse stageen
dc.typeinfo:eu-repo/semantics/article
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