Examination of the SGCE gene in Tourette's syndrome patients with obsessive-compulsive disorder

dc.contributor.authorAguiar, P. D.
dc.contributor.authorFazzari, M.
dc.contributor.authorJankovic, J.
dc.contributor.authorOzelius, L. J.
dc.contributor.institutionAlbert Einstein Coll Med
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionBaylor Coll Med
dc.date.accessioned2016-01-24T12:37:23Z
dc.date.available2016-01-24T12:37:23Z
dc.date.issued2004-10-01
dc.description.abstractMutations in the E-sarcoglycan gene (SGCE) have been reported in families with myoclonus-dystonia (M-D). in addition to abnormal movements, obsessive- compulsive disorder (OCD) has also been described in families with M-D. OCD is a common feature in another movement disorder, namely Tourette's syndrome (TS). the comorbidity of these disorders suggests that common genetic factors might be involved in their susceptibility. To evaluate this, we performed two sets of experiments. An association study using a polymorphism within an intron of the SGCE gene was assessed in patients with TS and OCD versus controls, and the SGCE gene itself was screened for mutations in all TS/OCD patients, followed by direct sequencing of the gene in a limited number of these patients. No correlation was found by either method. (C) 2004 Movement Disorder Society.en
dc.description.affiliationAlbert Einstein Coll Med, Dept Mol Genet, Bronx, NY 10461 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationAlbert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA
dc.description.affiliationBaylor Coll Med, Dept Neurol, Houston, TX 77030 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1237-1238
dc.identifierhttp://dx.doi.org/10.1002/mds.20156
dc.identifier.citationMovement Disorders. Hoboken: Wiley-liss, v. 19, n. 10, p. 1237-1238, 2004.
dc.identifier.doi10.1002/mds.20156
dc.identifier.issn0885-3185
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27955
dc.identifier.wosWOS:000224422000017
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMovement Disorders
dc.rightsAcesso restrito
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectmyoclonus-dystoniaen
dc.subjectepsilon-sarcoglycanen
dc.subjectTourette's syndromeen
dc.subjectobsessive-compulsive disorderen
dc.titleExamination of the SGCE gene in Tourette's syndrome patients with obsessive-compulsive disorderen
dc.typeArtigo
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